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Literature summary for 3.4.24.7 extracted from

  • Cao, Z.; Li, C.; Zhu, G.
    Inhibitory effects of baicalin on IL-1beta-induced MMP-1/TIMP-1 and its stimulated effect on collagen-I production in human periodontal ligament cells (2010), Eur. J. Pharmacol., 641, 1-6.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
tissue inhibitors of metalloproteinase-1 i.e. TIMP-1 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Type I collagen + H2O Homo sapiens production of type I collagen by periodontal ligament cells ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
periodontal ligament
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Type I collagen + H2O
-
Homo sapiens ?
-
?
Type I collagen + H2O production of type I collagen by periodontal ligament cells Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
matrix metalloproteinase-1
-
Homo sapiens
MMP-1
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens both the MMP-1 and TIMP-1 mRNA expression level are dramatically downregulated by baicalin down
Homo sapiens phorbol 12-myristate 13-acetate and interleukin-1beta significantly stimulate the production of MMP-1 by periodontal ligament cells at both the transcriptional and the translational level up

General Information

General Information Comment Organism
metabolism effects of baicalin on the total protein amount and collagen I mRNA expression in periodontal ligament cells, and the regulatory effects on MMP-1/TIMP-1 expression, overview Homo sapiens