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Literature summary for 3.4.24.7 extracted from
- Thyroid hormone induces myocardial matrix degradation by activating matrix metalloproteinase-1 (2007), Matrix Biol., 26, 269-279.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | dexamethasone induces myocardial matrix degradation by MMP-1 | Rattus norvegicus | |
| thyroid hormone | thyroid hormone induces myocardial matrix degradation by MMP-1 activation | Rattus norvegicus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| tissue inhibitor of matrix metalloproteinase-1 | - |
Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| collagen I + H2O | Rattus norvegicus | degradation | ? | - |
? |  |
| collagen III + H2O | Rattus norvegicus | degradation | ? | - |
? | |
| additional information | Rattus norvegicus | myocardial matrix degradation by MMP-1 induced by thyroid hormone through enzyme activation, enzyme regulation involving suppression of tissue inhibitors of matrix metalloproteinases TIMPs and distribution, overview | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
Sprague-Dawley rats | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| heart | the MMP-1 levels are altered in the left ventricle and serum in case of hypertrophy through hyperthyroid conditions with 3,5,3'-triiodo-L-thyroine or dexamethasone application, tissue distribution, overview | Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| collagen I + H2O | degradation | Rattus norvegicus | ? | - |
? | |
| collagen III + H2O | degradation | Rattus norvegicus | ? | - |
? | |
| additional information | myocardial matrix degradation by MMP-1 induced by thyroid hormone through enzyme activation, enzyme regulation involving suppression of tissue inhibitors of matrix metalloproteinases TIMPs and distribution, overview | Rattus norvegicus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| matrix metalloproteinase-1 | - |
Rattus norvegicus |
| MMP-1 | - |
Rattus norvegicus |
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