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Literature summary for 3.4.24.7 extracted from

  • Galardy, R.E.; Grobelny, D.; Kortylewicz, Z.P.; Poncz, L.
    Inhibition of human skin fibroblast collagenase by phosphorus-containing peptides (1992), Matrix Suppl., 1, 259-262.
    View publication on PubMed
Search for more literature for 3.4.24.7

Inhibitors

Inhibitors Comment Organism Structure
Ac-Pro-Leu-Gly-SCH(iBu)CO-Leu-Leu-GlyOEt pH 6.5, 25 °C, 50 mM HEPES buffer, 10 mM CaCl2, 1 mM 4,4'-dithiodipyridine Homo sapiens
C3H7-POOH-Ile-Trp-NHMe phosphonamidate inhibitor, pH 6.5, 25 °C, 50 mM HEPES buffer, 10 mM CaCl2, 1 mM 4,4'-dithiodipyridine Homo sapiens
EtO-POOH-CH2-Leu-Trp-NHMe pH 6.5, 25 °C, 50 mM HEPES buffer, 10 mM CaCl2, 1 mM 4,4'-dithiodipyridine Homo sapiens
EtO-POOH-Ile-Ala-Gly phosphoramidate inhibitor, pH 6.5, 25 °C, 50 mM HEPES buffer, 10 mM CaCl2, 1 mM 4,4'-dithiodipyridine, substrate Ac-Pro-Leu-Gly-SCH(iBu)CO-Leu-Leu-GlyOEt Homo sapiens
EtO-POOH-Ile-Ala-Gly-Gln-Arg-Gly phosphoramidate inhibitor, pH 6.5, 25 °C, 50 mM HEPES buffer, 10 mM CaCl2, 1 mM 4,4'-dithiodipyridine, substrate Ac-Pro-Leu-Gly-SCH(iBu)CO-Leu-Leu-GlyOEt, weak inhibition Homo sapiens
EtO-POOH-Ile-Ala-Gly-Glu-Arg(NO2)-Gly phosphoramidate inhibitor, pH 6.5, 25 °C, 50 mM HEPES buffer, 10 mM CaCl2, 1 mM 4,4'-dithiodipyridine, substrate Ac-Pro-Leu-Gly-SCH(iBu)CO-Leu-Leu-GlyOEt, weak inhibition Homo sapiens
EtO-POOH-Ile-Ala-Gly-Glu-Arg-Gly phosphoramidate inhibitor, pH 6.5, 25 °C, 50 mM HEPES buffer, 10 mM CaCl2, 1 mM 4,4'-dithiodipyridine, substrate Ac-Pro-Leu-Gly-SCH(iBu)CO-Leu-Leu-GlyOEt, weak inhibition Homo sapiens
EtO-POOH-Ile-Leu-Gly phosphoramidate inhibitor, pH 6.5, 25 °C, 50 mM HEPES buffer, 10 mM CaCl2, 1 mM 4,4'-dithiodipyridine, substrate Ac-Pro-Leu-Gly-SCH(iBu)CO-Leu-Leu-GlyOEt Homo sapiens
EtO-POOH-Ile-Trp-NHMe phosphoramidate inhibitor, pH 6.5, 25 °C, 50 mM HEPES buffer, 10 mM CaCl2, 1 mM 4,4'-dithiodipyridine, substrate Ac-Pro-Leu-Gly-SCH(iBu)CO-Leu-Leu-GlyOEt Homo sapiens
EtO-POOH-Ile-Tyr(OBzl)-Gly phosphoramidate inhibitor, pH 6.5, 25 °C, 50 mM HEPES buffer, 10 mM CaCl2, 1 mM 4,4'-dithiodipyridine, substrate Ac-Pro-Leu-Gly-SCH(iBu)CO-Leu-Leu-GlyOEt Homo sapiens
EtO-POOH-Ile-Tyr-Gly phosphoramidate inhibitor, pH 6.5, 25 °C, 50 mM HEPES buffer, 10 mM CaCl2, 1 mM 4,4'-dithiodipyridine, substrate Ac-Pro-Leu-Gly-SCH(iBu)CO-Leu-Leu-GlyOEt Homo sapiens
hexyl-POOH-CH2-Leu-Trp-NHMe pH 6.5, 25 °C, 50 mM HEPES buffer, 10 mM CaCl2, 1 mM 4,4'-dithiodipyridine Homo sapiens
hexyl-POOH-Leu-Trp-NHMe pH 6.5, 25 °C, 50 mM HEPES buffer, 10 mM CaCl2, 1 mM 4,4'-dithiodipyridine Homo sapiens
hexyl-POOH-O-Leu-Trp-NHMe pH 6.5, 25 °C, 50 mM HEPES buffer, 10 mM CaCl2, 1 mM 4,4'-dithiodipyridine Homo sapiens
naphthoyl-Gly-PSI[POOHCH2]-Leu-Trp-NHBzl pH 6.5, 25 °C, 50 mM HEPES buffer, 10 mM CaCl2, 1 mM 4,4'-dithiodipyridine Homo sapiens
phthaloyl-Gly(P)-Ile-Trp-(R)NHCH-(Me)Ph phosphonamidate inhibitor, pH 6.5, 25 °C, 50 mM HEPES buffer, 10 mM CaCl2, 1 mM 4,4'-dithiodipyridine Homo sapiens
phthaloyl-Gly-PSI[POOHNH]-Ile-Trp-(S)NHCH-(Me)Ph phosphonamidate inhibitor, pH 6.5, 25 °C, 50 mM HEPES buffer, 10 mM CaCl2, 1 mM 4,4'-dithiodipyridine Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 HSFC
-

Source Tissue

Source Tissue Comment Organism Textmining
skin fibroblast
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Ac-Pro-Leu-Gly-SCH2(iBu)CO-Leu-Leu-GlyOEt + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
HSFC
-
 Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.002
-
 phthaloyl-Gly-PSI[POOHNH]-Ile-Trp-(S)NHCH-(Me)Ph phosphonamidate inhibitor, pH 6.5, 25 °C, 50 mM HEPES buffer, 10 mM CaCl2, 1 mM 4,4'-dithiodipyridine Homo sapiens
0.002
-
 C3H7-POOH-Ile-Trp-NHMe phosphonamidate inhibitor, pH 6.5, 25 °C, 50 mM HEPES buffer, 10 mM CaCl2, 1 mM 4,4'-dithiodipyridine Homo sapiens
0.002
-
 EtO-POOH-Ile-Tyr(OBzl)-Gly phosphoramidate inhibitor, pH 6.5, 25 °C, 50 mM HEPES buffer, 10 mM CaCl2, 1 mM 4,4'-dithiodipyridine, substrate Ac-Pro-Leu-Gly-SCH(iBu)CO-Leu-Leu-GlyOEt Homo sapiens
0.004
-
 EtO-POOH-CH2-Leu-Trp-NHMe pH 6.5, 25 °C, 50 mM HEPES buffer, 10 mM CaCl2, 1 mM 4,4'-dithiodipyridine Homo sapiens
0.012
-
 EtO-POOH-Ile-Trp-NHMe phosphoramidate inhibitor, pH 6.5, 25 °C, 50 mM HEPES buffer, 10 mM CaCl2, 1 mM 4,4'-dithiodipyridine, substrate Ac-Pro-Leu-Gly-SCH(iBu)CO-Leu-Leu-GlyOEt Homo sapiens
0.02
-
 EtO-POOH-Ile-Tyr-Gly phosphoramidate inhibitor, pH 6.5, 25 °C, 50 mM HEPES buffer, 10 mM CaCl2, 1 mM 4,4'-dithiodipyridine, substrate Ac-Pro-Leu-Gly-SCH(iBu)CO-Leu-Leu-GlyOEt Homo sapiens
0.045
-
 EtO-POOH-Ile-Leu-Gly phosphoramidate inhibitor, pH 6.5, 25 °C, 50 mM HEPES buffer, 10 mM CaCl2, 1 mM 4,4'-dithiodipyridine, substrate Ac-Pro-Leu-Gly-SCH(iBu)CO-Leu-Leu-GlyOEt Homo sapiens
0.12
-
 EtO-POOH-Ile-Ala-Gly phosphoramidate inhibitor, pH 6.5, 25 °C, 50 mM HEPES buffer, 10 mM CaCl2, 1 mM 4,4'-dithiodipyridine, substrate Ac-Pro-Leu-Gly-SCH(iBu)CO-Leu-Leu-GlyOEt Homo sapiens
0.27
-
 EtO-POOH-Ile-Ala-Gly-Glu-Arg(NO2)-Gly phosphoramidate inhibitor, pH 6.5, 25 °C, 50 mM HEPES buffer, 10 mM CaCl2, 1 mM 4,4'-dithiodipyridine, substrate Ac-Pro-Leu-Gly-SCH(iBu)CO-Leu-Leu-GlyOEt, weak inhibition Homo sapiens
0.3
-
 hexyl-POOH-O-Leu-Trp-NHMe pH 6.5, 25 °C, 50 mM HEPES buffer, 10 mM CaCl2, 1 mM 4,4'-dithiodipyridine Homo sapiens
0.4
-
 EtO-POOH-Ile-Ala-Gly-Glu-Arg-Gly phosphoramidate inhibitor, pH 6.5, 25 °C, 50 mM HEPES buffer, 10 mM CaCl2, 1 mM 4,4'-dithiodipyridine, substrate Ac-Pro-Leu-Gly-SCH(iBu)CO-Leu-Leu-GlyOEt, weak inhibition Homo sapiens
0.5
-
 EtO-POOH-Ile-Ala-Gly-Gln-Arg-Gly phosphoramidate inhibitor, pH 6.5, 25 °C, 50 mM HEPES buffer, 10 mM CaCl2, 1 mM 4,4'-dithiodipyridine, substrate Ac-Pro-Leu-Gly-SCH(iBu)CO-Leu-Leu-GlyOEt, weak inhibition Homo sapiens