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Literature summary for 3.4.24.68 extracted from

  • Zuverink, M.; Chen, C.; Przedpelski, A.; Blum, F.; Barbieri, J.
    A heterologous reporter defines the role of the tetanus toxin interchain disulfide in light-chain translocation (2015), Infect. Immun., 83, 2714-2724 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
mutant enzyme R372A/Y375F fused to beta-lactamase, expressed in Escherichia coli BL21(DE3) cells Clostridium tetani

Protein Variants

Protein Variants Comment Organism
R372A/Y375F the enzyme activity is about125,000fold reduced in toxicity relative to native protein Clostridium tetani
S70A inactive Clostridium tetani

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
150000
-
gel filtration Clostridium tetani

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
vesicle associated membrane protein 2 + H2O Clostridium tetani
-
?
-
?

Organism

Organism UniProt Comment Textmining
Clostridium tetani
-
-
-

Purification (Commentary)

Purification (Comment) Organism
Ni-NTA agarose column chromatography Clostridium tetani

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
vesicle associated membrane protein 2 + H2O
-
Clostridium tetani ?
-
?

Synonyms

Synonyms Comment Organism
TeNT
-
Clostridium tetani
tetanus toxin
-
Clostridium tetani