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Literature summary for 3.4.24.65 extracted from

  • Taddese, S.; Weiss, A.S.; Neubert, R.H.; Schmelzer, C.E.
    Mapping of macrophage elastase cleavage sites in insoluble human skin elastin (2008), Matrix Biol., 27, 420-428.
    View publication on PubMed

Application

Application Comment Organism
drug development the enzyme is a target in treatment of degradative disease processes in the skin Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Elastin + H2O Homo sapiens MMP-12 is active against multiple extracellular protein substrates such as elastin, its effect on elastin is central to emphysema in the lung and photoaging of skin, its expression in the skin increases on photodamaged skin and upon aging ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation the catalytic domain of human recombinant MMP-12 expressed in Escherichia coli Homo sapiens
-
lung
-
Homo sapiens
-
skin
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Elastin + H2O MMP-12 is active against multiple extracellular protein substrates such as elastin, its effect on elastin is central to emphysema in the lung and photoaging of skin, its expression in the skin increases on photodamaged skin and upon aging Homo sapiens ?
-
?
Elastin + H2O cleavage site determination and peptide mapping by mass spectrometry, based on the human tropoelastin isoform 9 sequence, SwissProt accession number P15502-9, preference of amino acids Ala and Gly at subsites, overview Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
Macrophage elastase
-
Homo sapiens
MMP-12
-
Homo sapiens
More MMP-12 is a member of the family of matrix metalloproteinases, MMPs Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
assay at Homo sapiens