Application | Comment | Organism |
---|---|---|
drug development | the enzyme is a target in treatment of degradative disease processes in the skin | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Elastin + H2O | Homo sapiens | MMP-12 is active against multiple extracellular protein substrates such as elastin, its effect on elastin is central to emphysema in the lung and photoaging of skin, its expression in the skin increases on photodamaged skin and upon aging | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
commercial preparation | the catalytic domain of human recombinant MMP-12 expressed in Escherichia coli | Homo sapiens | - |
lung | - |
Homo sapiens | - |
skin | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Elastin + H2O | MMP-12 is active against multiple extracellular protein substrates such as elastin, its effect on elastin is central to emphysema in the lung and photoaging of skin, its expression in the skin increases on photodamaged skin and upon aging | Homo sapiens | ? | - |
? | |
Elastin + H2O | cleavage site determination and peptide mapping by mass spectrometry, based on the human tropoelastin isoform 9 sequence, SwissProt accession number P15502-9, preference of amino acids Ala and Gly at subsites, overview | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Macrophage elastase | - |
Homo sapiens |
MMP-12 | - |
Homo sapiens |
More | MMP-12 is a member of the family of matrix metalloproteinases, MMPs | Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Homo sapiens |