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Literature summary for 3.4.24.65 extracted from

  • Churg, A.; Wang, X.; Wang, R.D.; Meixner, S.C.; Pryzdial, E.L.; Wright, J.L.
    Alpha1-antitrypsin suppresses TNF-alpha and MMP-12 production by cigarette smoke-stimulated macrophages (2007), Am. J. Respir. Cell Mol. Biol., 37, 144-151.
    View publication on PubMed
Search for more literature for 3.4.24.65

Inhibitors

Inhibitors Comment Organism Structure
additional information alpha1-antitrypsin, hirudin, aprotinin, and pertussis toxin, the G-protein coupled receptor inhibitor, suppress TNF-alpha and MMP-12 production by cigarette smoke-stimulated macrophage, while the PAR-1 agonist TRAP increases the release of MMP-12 and TNF-alpha, overview, TNF-alpha release in alveolar macrophages is related to MMP-12 secretion, alpha1-antitrypsin does not inhibit the activation of the MMP-12 proenzyme Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular secretion from macrophages Mus musculus
-
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
54000
-
 x * 54000, inactive MMP-12 protenzyme, SDS-PAGE Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus protease-activated receptor 1, PAR-1, controls MMP-12 release ?
-
 ?
additional information Mus musculus C57BL/6 protease-activated receptor 1, PAR-1, controls MMP-12 release ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 C57BL/6 mice
-
Mus musculus C57BL/6
-
 C57BL/6 mice
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification the inactive MMP-12 protenzyme needs to be activated by cleavage to the mature form Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
macrophage alveolar Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
casein + H2O
-
 Mus musculus ?
-
 ?
casein + H2O
-
 Mus musculus C57BL/6 ?
-
 ?
additional information protease-activated receptor 1, PAR-1, controls MMP-12 release Mus musculus ?
-
 ?
additional information protease-activated receptor 1, PAR-1, controls MMP-12 release Mus musculus C57BL/6 ?
-
 ?

Subunits

Subunits Comment Organism
? x * 54000, inactive MMP-12 protenzyme, SDS-PAGE Mus musculus

Synonyms

Synonyms Comment Organism
MMP-12
-
 Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Mus musculus