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Literature summary for 3.4.24.65 extracted from

  • Pender, S.L.; Li, C.K.; Sabatino, A.D.; MacDonald, T.T.; Buckley, M.G.
    Role of macrophage metalloelastase in gut inflammation (2006), Ann. N. Y. Acad. Sci., 1072, 386-388.
    View publication on PubMed
Search for more literature for 3.4.24.65

Activating Compound

Activating Compound Comment Organism Structure
additional information MMP-12 expression is 11.9 and 7.3fold, respectively, induced by PWM- and alphaCD3+IL12, MMP-12 expression is increased 7.3fold in ulcerative colitis and 3.6fold in Crohn’s disease Mus musculus

Application

Application Comment Organism
medicine role in idiophathic diseases, may be even more important in the causation of inflammatory bowel disease than MMP-3, markedly upregulated in a T-cell-mediated model in inflammatory bowel disease, local immune response can increase MMP-12 expression in resident lamina propria macrophages Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information MMP-12 knockout mice, no mucosal damage when trinitrobenzene sulfonic acid is administered to the colons compared to severe colitis in wild type mice Mus musculus
additional information administration of trinitrobenzene sulphonic acid to the colons of MMP-12 knockout mice for 7 days does not lead to mucosal damage in contrast to wild-type mice which show severe colitis, overview Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular secretion from macrophages Mus musculus
-
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
22000
-
 x * 54000, inactive proenzyme, x * 45000, intermediate enzyme, x * 22000, mature active enzyme Mus musculus
45000
-
 x * 54000, inactive proenzyme, x * 45000, intermediate enzyme, x * 22000, mature active enzyme Mus musculus
54000
-
 x * 54000, inactive proenzyme, x * 45000, intermediate enzyme, x * 22000, mature active enzyme Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
casein + H2O Mus musculus degradation ?
-
 ?
Elastin + H2O Mus musculus degradation ?
-
 ?
Fibronectin + H2O Mus musculus degradation ?
-
 ?
Laminin + H2O Mus musculus degradation ?
-
 ?
additional information Mus musculus the enzyme is important for allowing macrophage migration through extracellular matrix, and probably plays an important role in the causation of inflammatory bowel disease, IBD, MMP-12 expression is increased in ulcerative colitis and in Crohn’s disease ?
-
 ?
type-IV collagen + H2O Mus musculus degradation ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification MMP-12 is synthesized as 54-kDa proenzyme that is processed into a 45-kDa and then a 22-kDa active form Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
macrophage
-
 Mus musculus
-
macrophage specific for Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
casein + H2O degradation Mus musculus ?
-
 ?
Elastin + H2O degradation Mus musculus ?
-
 ?
Fibronectin + H2O degradation Mus musculus ?
-
 ?
Laminin + H2O degradation Mus musculus ?
-
 ?
additional information the enzyme is important for allowing macrophage migration through extracellular matrix, and probably plays an important role in the causation of inflammatory bowel disease, IBD, MMP-12 expression is increased in ulcerative colitis and in Crohn’s disease Mus musculus ?
-
 ?
additional information no activity with interstitial collagens or gelatin Mus musculus ?
-
 ?
type-IV collagen + H2O degradation Mus musculus ?
-
 ?

Subunits

Subunits Comment Organism
? x * 54000, inactive proenzyme, x * 45000, intermediate enzyme, x * 22000, mature active enzyme Mus musculus
More MMP-12 is synthesized as 54-kDa proenzyme that is processed into a 45-kDa and then a 22-kDa active form Mus musculus

Synonyms

Synonyms Comment Organism
macrophage metalloelastase
-
 Mus musculus
MMP-12
-
 Mus musculus