Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Homo sapiens | 5739 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
phosphatase and tensin homologue-induced kinase 1 + H2O | Homo sapiens | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HEK-293T cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
phosphatase and tensin homologue-induced kinase 1 + H2O | - |
Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
heterodimer | - |
Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
MPP | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | reducing enzyme activity induces phosphatase and tensin homologue-induced kinase 1 accumulation at the mitochondrial surface, leading to Parkin recruitment and mitophagy | Homo sapiens |
metabolism | the enzyme plays a role in phosphatase and tensin homologue-induced kinase 1 (PINK1) import and mitochondrial quality control via the PINK1-Parkin pathway | Homo sapiens |