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Literature summary for 3.4.24.63 extracted from

  • Martin, B.L.; Conley, S.M.; Harris, R.S.; Stanley, C.D.; Niyitegeka, J.M.; Ongeri, E.M.
    Hypoxia associated proteolytic processing of OS-9 by the metalloproteinase meprin beta (2016), Int. J. Nephrol., 2016, 2851803 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
Mep1B, recombinant expression of homomeric meprin B used in human embryonic kidney (HEK293) cells, coexpression with meprin A (EC 3.4.24.18), recombinant expression of meprin B in MEDCK cells Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information generation of meprin alphabeta knockout mice (alphabetaKO) which lack endogenous meprins, phenotype after CoCl2 exposure, overview Mus musculus

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ a zinc-dependent metalloprotease Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
osteosarcoma-9 + H2O Mus musculus OS-9, specific degradation by meprin beta ?
-
?
osteosarcoma-9 + H2O Mus musculus C57BL/6 OS-9, specific degradation by meprin beta ?
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus Q61847
-
-
Mus musculus C57BL/6 Q61847
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification meprin beta is activated using limited trypsin proteolysis Mus musculus

Purification (Commentary)

Purification (Comment) Organism
recombinant meprin B from HEK-293 cells Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
osteosarcoma-9 + H2O OS-9, specific degradation by meprin beta Mus musculus ?
-
?
osteosarcoma-9 + H2O OS-9, purified recombinant human osteosarcoma-9 protein, specific degradation by meprin beta Mus musculus ?
-
?
osteosarcoma-9 + H2O OS-9, specific degradation by meprin beta Mus musculus C57BL/6 ?
-
?
osteosarcoma-9 + H2O OS-9, purified recombinant human osteosarcoma-9 protein, specific degradation by meprin beta Mus musculus C57BL/6 ?
-
?

Synonyms

Synonyms Comment Organism
meprin beta
-
Mus musculus
metalloproteinase meprin beta
-
Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
assay at Mus musculus

General Information

General Information Comment Organism
metabolism meprin metalloproteases play a role in the pathology of ischemia/reperfusion- (IR-) induced renal injury. The endoplasmic reticulum-associated protein, osteosarcoma-9 (OS-9), interacts with the C-terminal tail of meprin beta (two-hybrid system). OS-9 also interacts with the hypoxia inducible factor-1alpha (HIF-1alpha) and the prolyl-hydroxylase, proteins which mediate the cell's response to hypoxia. OS-9 proteins are most abundant in the cytosolic-enriched protein fraction of kidneys and does not occur in the brush border membrane-enriched fraction Mus musculus
physiological function meprin B cleaves kidney OS-9 in ischemia/reperfusion Mus musculus