Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.24.63 extracted from

  • Herzog, C.; Marisiddaiah, R.; Haun, R.; Kaushal, G.
    Basement membrane protein nidogen-1 is a target of meprin beta in cisplatin nephrotoxicity (2015), Toxicol. Lett., 236, 110-116.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.63

Protein Variants

Protein Variants Comment Organism
additional information generation and genotyping of meprin beta-knockout mice Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
actinonin markedly prevents urinary excretion of the cleaved nidogen-1 Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
brush border membrane
-
 Mus musculus 31526
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
nidogen-1 + H2O Mus musculus
-
 ?
-
 ?
nidogen-1 + H2O Mus musculus C57BL/6N
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q61847
-
-
Mus musculus C57BL/6N Q61847
-
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
 Mus musculus
-
additional information During acute kidney injury (AKI) induced by cisplatin or ischemia-reperfusion, membrane-bound meprins are shed and their localization is altered from the apical membranes toward the basolateral surface of the proximal tubules Mus musculus
-
renal proximal tubule
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
nidogen-1 + H2O
-
 Mus musculus ?
-
 ?
nidogen-1 + H2O
-
 Mus musculus C57BL/6N ?
-
 ?

General Information

General Information Comment Organism
malfunction meprin beta-deficient mice, but not meprin alpha-deficient mice, subjected to cisplatin nephrotoxicity, significantly suppress excretion of cleaved nidogen-1 Mus musculus
metabolism during acute kidney injury induced by cisplatin or ischemia-reperfusion, membrane-bound meprins are shed and their localization is altered from the apical membranes toward the basolateral surface of the proximal tubules. Meprins are capable of cleaving basement membrane proteins in vitro and in vivo Mus musculus
physiological function basement membrane protein nidogen-1 is a target of meprin beta in cisplatin nephrotoxicity Mus musculus