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Literature summary for 3.4.24.63 extracted from
- Role of interaction of mannan-binding protein with meprins at the initial step of complement activation in ischemia/reperfusion injury to mouse kidney (2012), Glycobiology, 22, 84-95.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | preparation of biotin-labeled mouse meprins | Mus musculus |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Zn2+ | metalloprotease | Mus musculus |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | Q61847 | - |
- |
| Mus musculus BALB/c | Q61847 | - |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| glycoprotein | the enzyme is highly glycosylated | Mus musculus |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| isolation of meprins from the mouse kidneys by immunoaffinity chromatography using mannan-binding protein resin | Mus musculus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| kidney | - |
Mus musculus | - |
| additional information | co-localization of the enzyme with serum-type mannan-binding protein and C3b on both the cortex and the medulla in the renal I/R-operated mouse kidney, overview | Mus musculus | - |
| renal proximal tubule | - |
Mus musculus | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| meprin beta | - |
Mus musculus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| metabolism | role of interaction of mannan-binding protein with meprins at the initial step of complement activation in ischemia/reperfusion injury to mouse kidney. Co-localization of the enzyme with serum-type mannan-binding protein and C3b on both the cortex and the medulla in the renal I/R-operated mouse kidney | Mus musculus |
| physiological function | serum-type mannan-binding protein interacts with meprins in vivo in the I/R-operated mouse kidney and initiates the complement activation through the interaction with meprins in vitro, overview | Mus musculus |
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