Literature summary for 3.4.24.63 extracted from

Bylander, J.; Li, Q.; Ramesh, G.; Zhang, B.; Reeves, W.B.; Bond, J.S.
Targeted disruption of the meprin metalloproteinase beta gene protects against renal ischemia-reperfusion injury in mice (2008), Am. J. Physiol., 294, F480-F490.

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Protein Variants

Protein Variants	Comment	Organism
additional information	homozygous knockout mice deficient in beta-subunit are produced from wild-type C57BL/6 mice with 129/Sv F2 embryonic stem cells and subjected to ischemia-reperfusion, they show a higher susceptability to renal injury, while wild-type mice show rapid redistribution of meprin beta-subunits in proximal tubule cells, overview	Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Mus musculus	the alpha/beta isoform is deleterious in case of ischemia-reperfusion, overview	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	C57BL/6 wild-type mice	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
kidney	proximal tubules, high expression level	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	the alpha/beta isoform is deleterious in case of ischemia-reperfusion, overview	Mus musculus	?	-	?

Subunits

Subunits	Comment	Organism
More	the enzyme is formed by alpha and/or beta subunits, the alpha/beta isoform is deleterious in case of ischemia-reperfusion, overview	Mus musculus

Synonyms

Synonyms	Comment	Organism
meprin metalloproteinase beta	-	Mus musculus

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Release 2023.1 (January 2023)