BRENDA - Enzyme Database show
show all sequences of 3.4.24.62

Evidence for the presence of pro-oxytocin/neurophysin-converting enzyme in the human ovary

Guillou, M.D.; Camier, M.; Clamagirand, C.; J. Endocrinol. 142, 345-352 (1994)

Data extracted from this reference:

Inhibitors
Inhibitors
Commentary
Organism
Structure
EDTA
-
Homo sapiens
additional information
no inhibition by PMSF, pepstatin
Homo sapiens
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
secretory granule
-
Homo sapiens
30141
-
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
60000
-
human
Homo sapiens
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
Pro-oxytocin/neurophysin + H2O
Homo sapiens
involved in post-translational processing
?
-
-
-
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
-
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
corpus luteum
-
Homo sapiens
-
ovary
granulosa cells and follicular fluid
Homo sapiens
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Pro-oxytocin/neurophysin + H2O
involved in post-translational processing
31376
Homo sapiens
?
-
-
-
-
Pro-oxytocin/neurophysin(1-20) + H2O
strictly selective for basic amino acid doublet Lys11-Arg12, cleavage site: Arg12-Ala13
31376
Homo sapiens
Pro-oxytocin/neurophysin(1-12) + pro-oxytocin/neurophysin(13-20)
i.e. peptide II (i.e. oxytocinGly10Lys11Arg12 and peptide III)
31376
Homo sapiens
-
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
EDTA
-
Homo sapiens
additional information
no inhibition by PMSF, pepstatin
Homo sapiens
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
secretory granule
-
Homo sapiens
30141
-
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
60000
-
human
Homo sapiens
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
Pro-oxytocin/neurophysin + H2O
Homo sapiens
involved in post-translational processing
?
-
-
-
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
corpus luteum
-
Homo sapiens
-
ovary
granulosa cells and follicular fluid
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Pro-oxytocin/neurophysin + H2O
involved in post-translational processing
31376
Homo sapiens
?
-
-
-
-
Pro-oxytocin/neurophysin(1-20) + H2O
strictly selective for basic amino acid doublet Lys11-Arg12, cleavage site: Arg12-Ala13
31376
Homo sapiens
Pro-oxytocin/neurophysin(1-12) + pro-oxytocin/neurophysin(13-20)
i.e. peptide II (i.e. oxytocinGly10Lys11Arg12 and peptide III)
31376
Homo sapiens
-
Other publictions for EC 3.4.24.62
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
668826
Rholam
-
Magnolysin ...
Bos taurus, Homo sapiens
Handbook Of Proteolytic Enzymes(Barrett,A. J. ,Rawlings,N. D. ,Woessner,J. F. ,Eds. )Academic Press
1
1039-1042
2004
-
-
-
-
-
-
12
-
-
-
2
-
-
2
-
-
2
-
-
4
-
-
4
2
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
12
-
-
-
-
2
-
-
-
-
2
-
4
-
-
4
2
-
-
-
-
2
-
-
-
-
-
-
-
-
-
31376
Guillou
Evidence for the presence of p ...
Homo sapiens
J. Endocrinol.
142
345-352
1994
-
-
-
-
-
-
2
-
1
-
1
1
-
1
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
1
-
1
1
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
31374
Brakch
Processing endoprotease recogn ...
Bos taurus
J. Biol. Chem.
264
15912-15916
1989
-
-
-
-
-
-
3
-
-
1
-
-
-
1
-
-
1
-
-
1
-
-
8
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
1
-
-
-
-
-
1
-
1
-
-
8
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
31375
Plevrakis
Proocytocin/neurophysin conver ...
Bos taurus
Biochemistry
28
2705-2710
1989
-
-
-
-
-
-
6
2
1
-
2
-
-
1
-
-
1
-
-
3
-
-
1
1
1
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
6
-
2
1
-
2
-
-
-
-
1
-
3
-
-
1
1
1
-
-
-
2
-
-
-
-
-
-
-
-
-
31370
Cohen
Somatostatin-28 and pro-ocytoc ...
Bos taurus
Biochimie
70
17-23
1988
-
-
-
-
-
-
1
-
1
1
-
-
-
1
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
1
-
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
31373
Creminon
Synthetic peptide substrates a ...
Bos taurus
J. Chromatogr.
440
439-448
1988
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
1
-
-
1
-
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7
-
1
-
-
-
-
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-
-
-
-
-
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-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
1
-
-
7
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
31371
Clamagirand
Partial purification and funct ...
Bos taurus
Biochemistry
26
6018-6023
1987
-
-
-
-
-
-
8
-
-
1
1
-
-
1
-
-
1
-
-
1
-
-
8
-
1
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
8
-
-
-
1
1
-
-
-
-
1
-
1
-
-
8
-
1
-
-
-
2
-
-
-
-
-
-
-
-
-
31372
Clamagirand
C-terminally extended ocytocin ...
Bos taurus
Biochem. Biophys. Res. Commun.
143
789-796
1987
-
-
-
-
-
-
5
-
1
-
-
-
-
1
-
-
1
-
-
1
-
-
4
-
1
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
5
-
-
1
-
-
-
-
-
-
1
-
1
-
-
4
-
1
-
-
-
2
-
-
-
-
-
-
-
-
-