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Literature summary for 3.4.24.59 extracted from

  • Marcondes, M.F.; Alves, F.M.; Assis, D.M.; Hirata, I.Y.; Juliano, L.; Oliveira, V.; Juliano, M.A.
    Substrate specificity of mitochondrial intermediate peptidase analysed by a support-bound peptide library (2015), FEBS open bio, 5, 429-436 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21 (DE3) pLysS cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information not inhibited by thiorphan, captopril, and JA-2 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00085
-
Abz-TTKLKAAK(Dnp)-NH2 in 50 mM Tris, 100 mM NaCl, pH 8.0, at 25°C Homo sapiens
0.000941
-
Abz-FRSGQPLQNKVQLQ-ED(Dnp) in 50 mM Tris, 100 mM NaCl, pH 8.0, at 25°C Homo sapiens
0.0011
-
Abz-IKQSSLLK(Dnp)-NH2 in 50 mM Tris, 100 mM NaCl, pH 8.0, at 25°C Homo sapiens
0.0013
-
Abz-NLMKKSTK(Dnp)-NH2 in 50 mM Tris, 100 mM NaCl, pH 8.0, at 25°C Homo sapiens
0.0013
-
Abz-FSSKTTVK(Dnp)-NH2 in 50 mM Tris, 100 mM NaCl, pH 8.0, at 25°C Homo sapiens
0.0018
-
Abz-VRNFRSGQPLQNKVQ-ED(Dnp) in 50 mM Tris, 100 mM NaCl, pH 8.0, at 25°C Homo sapiens
0.0019
-
Abz-VISSRLEK(Dnp)-NH2 in 50 mM Tris, 100 mM NaCl, pH 8.0, at 25°C Homo sapiens
0.0029
-
Abz-QPLQNKVQ-ED(Dnp) in 50 mM Tris, 100 mM NaCl, pH 8.0, at 25°C Homo sapiens
0.0032
-
Abz-QPLQAKVQ-ED(Dnp) in 50 mM Tris, 100 mM NaCl, pH 8.0, at 25°C Homo sapiens
0.0034
-
Abz-FQTKVAAK(Dnp)-NH2 in 50 mM Tris, 100 mM NaCl, pH 8.0, at 25°C Homo sapiens
0.0042
-
Abz-MTAALKTK(Dnp)-NH2 in 50 mM Tris, 100 mM NaCl, pH 8.0, at 25°C Homo sapiens
0.0051
-
Abz-QPLANKVQ-ED(Dnp) in 50 mM Tris, 100 mM NaCl, pH 8.0, at 25°C Homo sapiens
0.0062
-
Abz-WTTGGKAK(Dnp)-NH2 in 50 mM Tris, 100 mM NaCl, pH 8.0, at 25°C Homo sapiens
0.01
-
Abz-VAAQTKTK(Dnp)-NH2 in 50 mM Tris, 100 mM NaCl, pH 8.0, at 25°C Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Homo sapiens 5739
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
75000
-
1 * 75000, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Mitochondrial intermediate proteins + H2O Homo sapiens
-
?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
Ni-Sepharose column chromatography and Resource Q column chromatography Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Abz-FQTKVAAK(Dnp)-NH2 + H2O
-
Homo sapiens Abz-FQ + TKVAAK(Dnp)-NH2
-
?
Abz-FRSGQPLQNKVQLQ-ED(Dnp) + H2O
-
Homo sapiens Abz-FRSGQPLQ + NKVQLQ-ED(Dnp)
-
?
Abz-FSSKTTVK(Dnp)-NH2 + H2O
-
Homo sapiens Abz-FS + SKTTVK(Dnp)-NH2
-
?
Abz-IKQSSLLK(Dnp)-NH2 + H2O
-
Homo sapiens Abz-IKQ + SSLLK(Dnp)-NH2
-
?
Abz-MTAALKTK(Dnp)-NH2 + H2O
-
Homo sapiens Abz-MT + AALK + TK(Dnp)-NH2
-
?
Abz-NLMKKSTK(Dnp)-NH2 + H2O
-
Homo sapiens Abz-NLM + KKSTK(Dnp)-NH2
-
?
Abz-QPLANKVQ-ED(Dnp) + H2O
-
Homo sapiens Abz-QPLA + NKVQ-ED(Dnp)
-
?
Abz-QPLQAKVQ-ED(Dnp) + H2O
-
Homo sapiens Abz-QPLQ + AKVQ-ED(Dnp)
-
?
Abz-QPLQNKVQ-ED(Dnp) + H2O
-
Homo sapiens Abz-QPLQ + NKVQ-ED(Dnp)
-
?
Abz-TTKLKAAK(Dnp)-NH2 + H2O
-
Homo sapiens Abz-TTKL + L-Lys + L-Ala + AK(Dnp)-NH2
-
?
Abz-VAAQTKTK(Dnp)-NH2 + H2O
-
Homo sapiens Abz-VAA + QTKTK(Dnp)-NH2
-
?
Abz-VISSRLEK(Dnp)-NH2 + H2O
-
Homo sapiens Abz-VIS + SRLEK(Dnp)-NH2
-
?
Abz-VRNFRSGQPLQNKVQ-ED(Dnp) + H2O
-
Homo sapiens Abz-VRNFRSGQPLQ + NKVQ-ED(Dnp)
-
?
Abz-WTTGGKAK(Dnp)-NH2 + H2O
-
Homo sapiens Abz-WT + TGGKAK(Dnp)-NH2
-
?
Mitochondrial intermediate proteins + H2O
-
Homo sapiens ?
-
?

Subunits

Subunits Comment Organism
monomer 1 * 75000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
MIP
-
Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.0033
-
Abz-WTTGGKAK(Dnp)-NH2 in 50 mM Tris, 100 mM NaCl, pH 8.0, at 25°C Homo sapiens
0.028
-
Abz-NLMKKSTK(Dnp)-NH2 in 50 mM Tris, 100 mM NaCl, pH 8.0, at 25°C Homo sapiens
0.036
-
Abz-FSSKTTVK(Dnp)-NH2 in 50 mM Tris, 100 mM NaCl, pH 8.0, at 25°C Homo sapiens
0.05
-
Abz-VAAQTKTK(Dnp)-NH2 in 50 mM Tris, 100 mM NaCl, pH 8.0, at 25°C Homo sapiens
0.055
-
Abz-IKQSSLLK(Dnp)-NH2 in 50 mM Tris, 100 mM NaCl, pH 8.0, at 25°C Homo sapiens
0.057
-
Abz-FQTKVAAK(Dnp)-NH2 in 50 mM Tris, 100 mM NaCl, pH 8.0, at 25°C Homo sapiens
0.057
-
Abz-QPLANKVQ-ED(Dnp) in 50 mM Tris, 100 mM NaCl, pH 8.0, at 25°C Homo sapiens
0.061
-
Abz-QPLQNKVQ-ED(Dnp) in 50 mM Tris, 100 mM NaCl, pH 8.0, at 25°C Homo sapiens
0.07
-
Abz-TTKLKAAK(Dnp)-NH2 in 50 mM Tris, 100 mM NaCl, pH 8.0, at 25°C Homo sapiens
0.083
-
Abz-VISSRLEK(Dnp)-NH2 in 50 mM Tris, 100 mM NaCl, pH 8.0, at 25°C Homo sapiens
0.0943
-
Abz-QPLQAKVQ-ED(Dnp) in 50 mM Tris, 100 mM NaCl, pH 8.0, at 25°C Homo sapiens
0.122
-
Abz-FRSGQPLQNKVQLQ-ED(Dnp) in 50 mM Tris, 100 mM NaCl, pH 8.0, at 25°C Homo sapiens
0.19
-
Abz-MTAALKTK(Dnp)-NH2 in 50 mM Tris, 100 mM NaCl, pH 8.0, at 25°C Homo sapiens
0.223
-
Abz-VRNFRSGQPLQNKVQ-ED(Dnp) in 50 mM Tris, 100 mM NaCl, pH 8.0, at 25°C Homo sapiens

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
0.53
-
Abz-WTTGGKAK(Dnp)-NH2 in 50 mM Tris, 100 mM NaCl, pH 8.0, at 25°C Homo sapiens
5
-
Abz-VAAQTKTK(Dnp)-NH2 in 50 mM Tris, 100 mM NaCl, pH 8.0, at 25°C Homo sapiens
11
-
Abz-QPLANKVQ-ED(Dnp) in 50 mM Tris, 100 mM NaCl, pH 8.0, at 25°C Homo sapiens
17
-
Abz-FQTKVAAK(Dnp)-NH2 in 50 mM Tris, 100 mM NaCl, pH 8.0, at 25°C Homo sapiens
21
-
Abz-QPLQNKVQ-ED(Dnp) in 50 mM Tris, 100 mM NaCl, pH 8.0, at 25°C Homo sapiens
22
-
Abz-NLMKKSTK(Dnp)-NH2 in 50 mM Tris, 100 mM NaCl, pH 8.0, at 25°C Homo sapiens
28
-
Abz-FSSKTTVK(Dnp)-NH2 in 50 mM Tris, 100 mM NaCl, pH 8.0, at 25°C Homo sapiens
29
-
Abz-QPLQAKVQ-ED(Dnp) in 50 mM Tris, 100 mM NaCl, pH 8.0, at 25°C Homo sapiens
44
-
Abz-VISSRLEK(Dnp)-NH2 in 50 mM Tris, 100 mM NaCl, pH 8.0, at 25°C Homo sapiens
45
-
Abz-MTAALKTK(Dnp)-NH2 in 50 mM Tris, 100 mM NaCl, pH 8.0, at 25°C Homo sapiens
50
-
Abz-IKQSSLLK(Dnp)-NH2 in 50 mM Tris, 100 mM NaCl, pH 8.0, at 25°C Homo sapiens
82
-
Abz-TTKLKAAK(Dnp)-NH2 in 50 mM Tris, 100 mM NaCl, pH 8.0, at 25°C Homo sapiens
124
-
Abz-VRNFRSGQPLQNKVQ-ED(Dnp) in 50 mM Tris, 100 mM NaCl, pH 8.0, at 25°C Homo sapiens
130
-
Abz-FRSGQPLQNKVQLQ-ED(Dnp) in 50 mM Tris, 100 mM NaCl, pH 8.0, at 25°C Homo sapiens