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Literature summary for 3.4.24.57 extracted from

  • Zheng, L.; Yu, C.; Bayles, K.; Lasa, I.; Ji, Y.
    Conditional mutation of an essential putative glycoprotease eliminates autolysis in Staphylococcus aureus (2007), J. Bacteriol., 189, 2734-2742.
    View publication on PubMedView publication on EuropePMC
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Activating Compound

Activating Compound Comment Organism Structure
additional information Gcp may function independently from several key autolysins, e.g. Atl, LytM, and LytN, and regulators, e.g. ArlRS, Mgr/Rat, and CidA, overview Staphylococcus aureus

Application

Application Comment Organism
drug development Gcp may be a target for developing antibacterial agents Staphylococcus aureus

Protein Variants

Protein Variants Comment Organism
additional information construction of a spacp-regulated gcp expression strain and a TetR-regulated gcp antisense expression strain, the down-regulation of gcp expression can effectively inhibit Triton X-100-induced lysis, eliminate penicillin- and vancomycin-caused cell lysis, and dramatically increase tolerance to hydrolases, overview Staphylococcus aureus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Staphylococcus aureus Gcp is required for growth and is essential for bacteria, the essential Gcp is involved in the modification of substrates of murein hydrolases as well as in the regulation of expression and/or activity of some murein hydrolases, which, in turn, may play important roles in bacterial viability, Gcp may function independently from several key autolysins, e.g. Atl, LytM, and LytN, and regulators, e.g. ArlRS, Mgr/Rat, and CidA, overview ?
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Organism

Organism UniProt Comment Textmining
Staphylococcus aureus
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 gene gcp
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information Gcp is required for growth and is essential for bacteria, the essential Gcp is involved in the modification of substrates of murein hydrolases as well as in the regulation of expression and/or activity of some murein hydrolases, which, in turn, may play important roles in bacterial viability, Gcp may function independently from several key autolysins, e.g. Atl, LytM, and LytN, and regulators, e.g. ArlRS, Mgr/Rat, and CidA, overview Staphylococcus aureus ?
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Synonyms

Synonyms Comment Organism
Gcp
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 Staphylococcus aureus
Glycoprotease
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 Staphylococcus aureus