Activating Compound | Comment | Organism | Structure |
---|---|---|---|
resveratrol | incubation with resveratrol results in a substantial increase in Abeta42 fragmentation compared to the control, signifying that the polyphenol sustains insulin-degrading enzyme-dependent degradation of Abeta42 and its fragments | Homo sapiens |
Application | Comment | Organism |
---|---|---|
medicine | therapeutic and/or preventative approaches combining resveratrol and insulin-degrading enzyme may hold promise for sporadic Alzheimer's disease | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
glutathione S-transferase-tagged human insulin-degrading enzyme in pGEX-6p-1 vector is transformed into Escherichia coli BL21-CodonPlus (DE3) competent cells | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Abeta42 + H2O | Homo sapiens | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P14735 | - |
- |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Abeta42 + H2O | - |
Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Insulin-degrading enzyme | - |
Homo sapiens |