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Literature summary for 3.4.24.56 extracted from

  • Du, J.; Zhang, L.; Liu, S.; Wang, Z.
    Palmitic acid and docosahexaenoic acid opposingly regulate the expression of insulin-degrading enzyme in neurons (2010), Pharmazie, 65, 231-232.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
amyloid beta + H2O Rattus norvegicus
-
amyloid beta peptide fragments
-
?
insulin + H2O Rattus norvegicus
-
insulin peptide fragments
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
Sprague-Dawley rat
-

Source Tissue

Source Tissue Comment Organism Textmining
hippocampus fetal Rattus norvegicus
-
neuron
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
amyloid beta + H2O
-
Rattus norvegicus amyloid beta peptide fragments
-
?
insulin + H2O
-
Rattus norvegicus insulin peptide fragments
-
?

Synonyms

Synonyms Comment Organism
IDE
-
Rattus norvegicus
Insulin-degrading enzyme
-
Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus palmitic acid suppresses the expression of IDE and induces Alzheimer's disease down
Rattus norvegicus docosahexaenoic acid induces the expression of IDE in primary hippocampal neurons and prevents Alzheimer's disease up

General Information

General Information Comment Organism
metabolism palmitic acid and docosahexaenoic acid opposingly regulate the expression of insulin-degrading enzyme in neurons Rattus norvegicus
additional information IDE activity protects against Alzheimer's disease, IDE suppression of IDE induces the pathology Rattus norvegicus
physiological function IDE is an important protease responsible for the degradation of amyloid-beta in neural cells Rattus norvegicus