Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
amyloid beta + H2O | Rattus norvegicus | - |
amyloid beta peptide fragments | - |
? | |
insulin + H2O | Rattus norvegicus | - |
insulin peptide fragments | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
Sprague-Dawley rat | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
hippocampus | fetal | Rattus norvegicus | - |
neuron | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
amyloid beta + H2O | - |
Rattus norvegicus | amyloid beta peptide fragments | - |
? | |
insulin + H2O | - |
Rattus norvegicus | insulin peptide fragments | - |
? |
Synonyms | Comment | Organism |
---|---|---|
IDE | - |
Rattus norvegicus |
Insulin-degrading enzyme | - |
Rattus norvegicus |
Organism | Comment | Expression |
---|---|---|
Rattus norvegicus | palmitic acid suppresses the expression of IDE and induces Alzheimer's disease | down |
Rattus norvegicus | docosahexaenoic acid induces the expression of IDE in primary hippocampal neurons and prevents Alzheimer's disease | up |
General Information | Comment | Organism |
---|---|---|
metabolism | palmitic acid and docosahexaenoic acid opposingly regulate the expression of insulin-degrading enzyme in neurons | Rattus norvegicus |
additional information | IDE activity protects against Alzheimer's disease, IDE suppression of IDE induces the pathology | Rattus norvegicus |
physiological function | IDE is an important protease responsible for the degradation of amyloid-beta in neural cells | Rattus norvegicus |