Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.24.56 extracted from

  • Du, J.; Zhang, L.; Liu, S.; Zhang, C.; Huang, X.; Li, J.; Zhao, N.; Wang, Z.
    PPARgamma transcriptionally regulates the expression of insulin-degrading enzyme in primary neurons (2009), Biochem. Biophys. Res. Commun., 383, 485-490.
    View publication on PubMed
Search for more literature for 3.4.24.56

Cloned(Commentary)

Cloned (Comment) Organism
IDE expression analysis in neuron tissue, overview Homo sapiens
IDE expression analysis in neuron tissue, overview Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
amyloid beta + H2O Homo sapiens
-
 amyloid beta peptide fragments
-
 ?
amyloid beta + H2O Rattus norvegicus
-
 amyloid beta peptide fragments
-
 ?
insulin + H2O Homo sapiens
-
 insulin peptide fragments
-
 ?
insulin + H2O Rattus norvegicus
-
 insulin peptide fragments
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Rattus norvegicus
-
 Sprague-Dawley rats
-

Source Tissue

Source Tissue Comment Organism Textmining
cerebellum
-
 Rattus norvegicus
-
granulocyte from type 2 diabetes mellitus patients and control subjects Homo sapiens
-
hippocampus
-
 Rattus norvegicus
-
neuron primary culture, immunohistochemic expression analysis, overview Homo sapiens
-
neuron primary culture, immunohistochemic expression analysis, overview Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
amyloid beta + H2O
-
 Homo sapiens amyloid beta peptide fragments
-
 ?
amyloid beta + H2O
-
 Rattus norvegicus amyloid beta peptide fragments
-
 ?
insulin + H2O
-
 Homo sapiens insulin peptide fragments
-
 ?
insulin + H2O
-
 Rattus norvegicus insulin peptide fragments
-
 ?

Synonyms

Synonyms Comment Organism
IDE
-
 Homo sapiens
IDE
-
 Rattus norvegicus
Insulin-degrading enzyme
-
 Homo sapiens
Insulin-degrading enzyme
-
 Rattus norvegicus

Expression

Organism Comment Expression
Homo sapiens IDE levels are decreased in type 2 diabetes mellitus. IDE levels are significantly inversely correlated with plasma insulin, fasting blood glucose, triglyceride, total cholesterol, low-density lipoprotein, but not high-density lipoprotein down
Homo sapiens peroxisome proliferator-activated receptor gamma, PPARgamma, increases IDE levels acting as a positive regulator. PPARgamma participates in the insulin-induced IDE expression in neurons, it binds to the IDE gene promoter flanking a functional PPRE in primary neurons up
Rattus norvegicus peroxisome proliferator-activated receptor gamma, PPARgamma, increases IDE levels acting as a positive regulator. PPARgamma participates in the insulin-induced IDE expression in neurons, it binds to the IDE gene promoter flanking a functional PPRE in primary neurons up

General Information

General Information Comment Organism
malfunction deficiency in IDE function is associated with Alzheimer's disease and type 2 diabetes mellitus pathology. IDE levels are decreased in type 2 diabetes mellitus. Regulation of IDE by PPARgamma and their roles in Alzheimer's disease and type 2 diabetes mellitus pathology Homo sapiens
metabolism IDE levels are significantly inversely correlated with plasma insulin, fasting blood glucose, triglyceride, total cholesterol, low-density lipoprotein, but not high-density lipoprotein, indicating IDE is possibly involved in insulin turnover and its effects on carbohydrate and lipid metabolism, overview Homo sapiens
physiological function IDE plays a key role in degrading both amyloid beta and insulin Homo sapiens
physiological function IDE plays a key role in degrading both amyloid beta and insulin Rattus norvegicus