Any feedback?
Literature summary for 3.4.24.56 extracted from
- Degradation of relaxin family peptides by insulin-degrading enzyme (2009), Ann. N. Y. Acad. Sci., 1160, 38-41.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 1,10-phenanthroline | a Zn-chelator | Rattus norvegicus |  |
| InsL3 | competitively inhibits the degradation of insulin, and crosslinking of insulin to IDE | Rattus norvegicus | |
| relaxin | competitively inhibits the degradation of insulin, and crosslinking of insulin to IDE | Rattus norvegicus | |
| relaxin-3 | competitively inhibits the degradation of insulin, and crosslinking of insulin to IDE | Rattus norvegicus |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Zn2+ | dependent on | Rattus norvegicus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| InsL3 + H2O | Rattus norvegicus | - |
InsL3 fragments | - |
? | |
| insulin + H2O | Rattus norvegicus | - |
insulin fragments | - |
? | |
| relaxin + H2O | Rattus norvegicus | - |
relaxin fragments | - |
? | |
| relaxin-3 + H2O | Rattus norvegicus | - |
relaxin-3 fragments | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| native enzyme from liver by a series of chromatographic steps | Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
| additional information | IDE is a ubiquitously expressed metalloproteinase | Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| InsL3 + H2O | - |
Rattus norvegicus | InsL3 fragments | - |
? | |
| InsL3 + H2O | human substrate, degradation | Rattus norvegicus | InsL3 fragments | - |
? | |
| insulin + H2O | - |
Rattus norvegicus | insulin fragments | - |
? | |
| insulin + H2O | degradation | Rattus norvegicus | insulin fragments | - |
? | |
| relaxin + H2O | - |
Rattus norvegicus | relaxin fragments | - |
? | |
| relaxin + H2O | procine substrate, degradation | Rattus norvegicus | relaxin fragments | - |
? | |
| relaxin-3 + H2O | - |
Rattus norvegicus | relaxin-3 fragments | - |
? | |
| relaxin-3 + H2O | human substrate, degradation | Rattus norvegicus | relaxin-3 fragments | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| IDE | - |
Rattus norvegicus |
| Insulin-degrading enzyme | - |
Rattus norvegicus |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.0000444 | - |
pH not specified in the publication, temperature not specified in the publication | Rattus norvegicus | InsL3 | |
| 0.0000537 | - |
pH not specified in the publication, temperature not specified in the publication | Rattus norvegicus | relaxin-3 | |
| 0.000182 | - |
pH not specified in the publication, temperature not specified in the publication | Rattus norvegicus | relaxin |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | IDE is a ubiquitously expressed metalloproteinase responsible for the intracellular degradation of insulin, but possibly also for the cellular proteolysis of relaxin, InsL3 and relaxin-3 | Rattus norvegicus |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
