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Literature summary for 3.4.24.56 extracted from
- Insulin, insulin-degrading enzyme and amyloid beta-peptide in Alzheimers disease: review and hypothesis (2006), Neurobiol. Aging, 27, 190-198.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | construction of transgenic mice with increased enzyme levels show that the enzyme prevents and treats Alzheimer's disease formation | Rattus norvegicus |
| additional information | enzyme deficiency leads to development of either Alzheimer's disease and type 2 diabetes, overview | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Mus musculus | 5829 | - |
| cytosol | - |
Homo sapiens | 5829 | - |
| cytosol | - |
Rattus norvegicus | 5829 | - |
| extracellular | - |
Mus musculus | - |
- |
| extracellular | - |
Homo sapiens | - |
- |
| extracellular | - |
Rattus norvegicus | - |
- |
| peroxisome | - |
Mus musculus | 5777 | - |
| peroxisome | - |
Homo sapiens | 5777 | - |
| peroxisome | - |
Rattus norvegicus | 5777 | - |
| plasma membrane | - |
Mus musculus | 5886 | - |
| plasma membrane | - |
Homo sapiens | 5886 | - |
| plasma membrane | - |
Rattus norvegicus | 5886 | - |
| rough endoplasmic reticulum | - |
Mus musculus | 5791 | - |
| rough endoplasmic reticulum | - |
Homo sapiens | 5791 | - |
| rough endoplasmic reticulum | - |
Rattus norvegicus | 5791 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| thiol | the enzyme is a neutral thiol metalloprotease requiring both free thiol and divalent cations for activity | Mus musculus |  |
| thiol | the enzyme is a neutral thiol metalloprotease requiring both free thiol and divalent cations for activity | Homo sapiens | |
| thiol | the enzyme is a neutral thiol metalloprotease requiring both free thiol and divalent cations for activity | Rattus norvegicus | |
| Zn2+ | the enzyme is a neutral thiol metalloprotease requiring both free thiol and divalent cations for activity | Mus musculus | |
| Zn2+ | the enzyme is a neutral thiol metalloprotease requiring both free thiol and divalent cations for activity | Homo sapiens | |
| Zn2+ | the enzyme is a neutral thiol metalloprotease requiring both free thiol and divalent cations for activity | Rattus norvegicus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| amylin + H2O | Mus musculus | degradation | ? | - |
? | |
| amylin + H2O | Homo sapiens | degradation | ? | - |
? | |
| amylin + H2O | Rattus norvegicus | degradation | ? | - |
? | |
| amyloid beta-peptide + H2O | Mus musculus | degradation | ? | - |
? | |
| amyloid beta-peptide + H2O | Homo sapiens | degradation | ? | - |
? | |
| amyloid beta-peptide + H2O | Rattus norvegicus | degradation | ? | - |
? | |
| insulin + H2O | Mus musculus | degradation, reduced insulin degradation leads to type 2 diabetes, regulation, overview | ? | - |
? | |
| insulin + H2O | Homo sapiens | degradation, reduced insulin degradation leads to type 2 diabetes, regulation, overview | ? | - |
? | |
| insulin + H2O | Rattus norvegicus | degradation, reduced insulin degradation leads to type 2 diabetes, regulation, overview | ? | - |
? | |
| additional information | Mus musculus | hyperinsulinemia is probably elevated through insulin's competition with amyloid beta-peptide for the enzyme, IDE deficiency might be involved in development of Alzheimer's disease, regulation, overview | ? | - |
? | |
| additional information | Rattus norvegicus | hyperinsulinemia is probably elevated through insulin's competition with amyloid beta-peptide for the enzyme, IDE deficiency might be involved in development of Alzheimer's disease, regulation, overview | ? | - |
? | |
| additional information | Homo sapiens | hyperinsulinemia is probably elevated through insulin's competitition with amyloid beta-peptide for the enzyme, IDE deficiency might be involved in development of Alzheimer's disease, regulation, overview | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Mus musculus | - |
| brain | high expression level, increased expression level during development | Homo sapiens | - |
| brain | high expression level, increased expression level during development | Rattus norvegicus | - |
| liver | - |
Mus musculus | - |
| liver | high expression level | Homo sapiens | - |
| liver | high expression level | Rattus norvegicus | - |
| additional information | ubiquitous tissue expression | Mus musculus | - |
| additional information | ubiquitous tissue expression | Homo sapiens | - |
| additional information | ubiquitous tissue expression | Rattus norvegicus | - |
| muscle | - |
Mus musculus | - |
| muscle | high expression level | Homo sapiens | - |
| muscle | high expression level | Rattus norvegicus | - |
| testis | - |
Mus musculus | - |
| testis | high expression level, increased expression level during development | Homo sapiens | - |
| testis | high expression level, increased expression level during development | Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| amylin + H2O | degradation | Mus musculus | ? | - |
? | |
| amylin + H2O | degradation | Homo sapiens | ? | - |
? | |
| amylin + H2O | degradation | Rattus norvegicus | ? | - |
? | |
| amyloid beta-peptide + H2O | degradation | Mus musculus | ? | - |
? | |
| amyloid beta-peptide + H2O | degradation | Homo sapiens | ? | - |
? | |
| amyloid beta-peptide + H2O | degradation | Rattus norvegicus | ? | - |
? | |
| insulin + H2O | degradation | Mus musculus | ? | - |
? | |
| insulin + H2O | degradation | Homo sapiens | ? | - |
? | |
| insulin + H2O | degradation | Rattus norvegicus | ? | - |
? | |
| insulin + H2O | degradation, reduced insulin degradation leads to type 2 diabetes, regulation, overview | Mus musculus | ? | - |
? | |
| insulin + H2O | degradation, reduced insulin degradation leads to type 2 diabetes, regulation, overview | Homo sapiens | ? | - |
? | |
| insulin + H2O | degradation, reduced insulin degradation leads to type 2 diabetes, regulation, overview | Rattus norvegicus | ? | - |
? | |
| additional information | hyperinsulinemia is probably elevated through insulin's competition with amyloid beta-peptide for the enzyme, IDE deficiency might be involved in development of Alzheimer's disease, regulation, overview | Mus musculus | ? | - |
? | |
| additional information | hyperinsulinemia is probably elevated through insulin's competition with amyloid beta-peptide for the enzyme, IDE deficiency might be involved in development of Alzheimer's disease, regulation, overview | Rattus norvegicus | ? | - |
? | |
| additional information | hyperinsulinemia is probably elevated through insulin's competitition with amyloid beta-peptide for the enzyme, IDE deficiency might be involved in development of Alzheimer's disease, regulation, overview | Homo sapiens | ? | - |
? | |
| additional information | the enzyme is a neutral thiol metalloprotease with the active site sequence HEXXH | Mus musculus | ? | - |
? | |
| additional information | the enzyme is a neutral thiol metalloprotease with the active site sequence HEXXH | Homo sapiens | ? | - |
? | |
| additional information | the enzyme is a neutral thiol metalloprotease with the active site sequence HEXXH | Rattus norvegicus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| IDE | - |
Mus musculus |
| IDE | - |
Homo sapiens |
| IDE | - |
Rattus norvegicus |
| Insulin-degrading enzyme | - |
Mus musculus |
| Insulin-degrading enzyme | - |
Homo sapiens |
| Insulin-degrading enzyme | - |
Rattus norvegicus |
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