Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | fibrillar amyloid beta-peptide induces the enzyme in astrocytes through activation of a MAPK cascade via ERK1/2 | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | Tg3576 transgenic mice express the Swedish mutant of amyloid beta-peptide, the expression and activity of IDE in the transgenic mice is increased with age around plaques as a component of astrocyte activation due to amyloid beta-peptide-triggered inflammation in contrast to the behaviour in Alzheimer mice, overview | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
amyloid beta-peptide + H2O | Mus musculus | IDE is involved in clearance of amyloid-beta pepetide in the brain, enzyme deficiency may participate in the progression of Alzheimer's disease | ? | - |
? | |
insulin + H2O | Mus musculus | degradation | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
astrocyte | primary | Mus musculus | - |
brain | mutant brains expressing the Swedish mutant precursor of amyloid beta-peptide, enzyme level, activity and distribution, immunohistochemic analysis, overview | Mus musculus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
quantitative enzyme expression analysis by comeptitive RT-PCR, age-related insulin degradation in trangenic mice, radiolabeled substrate, overview | Mus musculus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
amyloid beta-peptide + H2O | degradation | Mus musculus | ? | - |
? | |
amyloid beta-peptide + H2O | IDE is involved in clearance of amyloid-beta pepetide in the brain, enzyme deficiency may participate in the progression of Alzheimer's disease | Mus musculus | ? | - |
? | |
insulin + H2O | degradation | Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
IDE | - |
Mus musculus |
Insulin-degrading enzyme | - |
Mus musculus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Mus musculus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7 | - |
assay at | Mus musculus |