Crystallization (Comment) | Organism |
---|---|
mutant E111Q in complex with substrates insulin B-chain, amyloid beta-protein, amylin and glucagon. Enzyme forms an enclosed cage just large enough to encapsulate insulin. enclosed substrate undergoes conformational changes to form beta-sheets with two discrete regions of enzyme for degradation | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
D426C/K899C | 30-40fold increase in activity compared to wild-type | Homo sapiens |
E111Q | crystallization data | Homo sapiens |
N184C/Q828C | 30-40fold increase in activity compared to wild-type | Homo sapiens |
S132C/E817C | 30-40fold increase in activity compared to wild-type | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
amylin + H2O | - |
Homo sapiens | ? | - |
? | |
amyloid beta-protein + H2O | - |
Homo sapiens | ? | - |
? | |
Glucagon + H2O | - |
Homo sapiens | ? | - |
? | |
Insulin B-chain + H2O | - |
Homo sapiens | ? | - |
? |