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Literature summary for 3.4.24.56 extracted from
- Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism (2006), Nature, 443, 870-874.
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
| mutant E111Q in complex with substrates insulin B-chain, amyloid beta-protein, amylin and glucagon. Enzyme forms an enclosed cage just large enough to encapsulate insulin. enclosed substrate undergoes conformational changes to form beta-sheets with two discrete regions of enzyme for degradation | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| D426C/K899C | 30-40fold increase in activity compared to wild-type | Homo sapiens |
| E111Q | crystallization data | Homo sapiens |
| N184C/Q828C | 30-40fold increase in activity compared to wild-type | Homo sapiens |
| S132C/E817C | 30-40fold increase in activity compared to wild-type | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| amylin + H2O | - |
Homo sapiens | ? | - |
? |  |
| amyloid beta-protein + H2O | - |
Homo sapiens | ? | - |
? | |
| Glucagon + H2O | - |
Homo sapiens | ? | - |
? | |
| Insulin B-chain + H2O | - |
Homo sapiens | ? | - |
? | |
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Release 2023.1 (January 2023)
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