Literature summary for 3.4.24.56 extracted from

Lynch, J.A.; George, A.M.; Eisenhauer, P.B.; Conn, K.; Gao, W.; Carreras, I.; Wells, J.M.; McKee, A.; Ullman, M.D.; Fine, R.E.
Insulin degrading enzyme is localized predominantly at the cell surface of polarized and unpolarized human cerebrovascular endothelial cell cultures (2006), J. Neurosci. Res., 83, 1262-1270.

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
extracellular	associated to plasma membrane, mainly at basolateral cell surface	Homo sapiens	-	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
cerebrovascular endothelial cell	cells express enzyme and respond to exposure to low levels of amyloid beta-protein by upregulation of enzyme expression	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
amyloid beta-protein + H2O	-	Homo sapiens	?	-	?
insulin + H2O	-	Homo sapiens	?	-	?

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Release 2023.1 (January 2023)