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Literature summary for 3.4.24.56 extracted from

  • Farris, W.; Leissring, M.A.; Hemming, M.L.; Chang, A.Y.; Selkoe, D.J.
    Alternative splicing of human insulin-degrading enzyme yields a novel isoform with a decreased ability to degrade insulin and amyloid beta-protein (2005), Biochemistry, 44, 6513-6525.
    View publication on PubMed

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0000657
-
Insulin isoform 15a-IDE, pH 7.4, 37°C Homo sapiens
0.000222
-
Insulin isoform 15b-IDE, pH 7.4, 37°C Homo sapiens
0.00123
-
amyloid beta-protein isoform 15a-IDE, pH 7.4, 37°C Homo sapiens
0.00252
-
amyloid beta-protein isoform 15b-IDE, pH 7.4, 37°C Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol isoform IDE-15b, both in cytosol and mitochondrion Homo sapiens 5829
-
mitochondrion isoform IDE-15b, both in cytosol and mitochondrion Homo sapiens 5739
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
113000
-
2 * 113000, homodimer or heterodimer of isoforms 15a-IDE and 15b-IDE, SDS-PAGE Homo sapiens
220000
-
native PAGE Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P14735 isoform IDE-15a using the canonical exon 15a; identification of six distinct enzyme transcripts, in isoform IDE-15b exon 15b replaces the canonical exon 15a
-

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
amyloid beta-protein + H2O
-
Homo sapiens ?
-
?
insulin + H2O
-
Homo sapiens ?
-
?

Subunits

Subunits Comment Organism
dimer 2 * 113000, homodimer or heterodimer of isoforms 15a-IDE and 15b-IDE, SDS-PAGE Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.017
-
Insulin isoform 15b-IDE, pH 7.4, 37°C Homo sapiens
0.025
-
Insulin isoform 15a-IDE, pH 7.4, 37°C Homo sapiens
0.17
-
amyloid beta-protein isoform 15b-IDE, pH 7.4, 37°C Homo sapiens
0.88
-
amyloid beta-protein isoform 15a-IDE, pH 7.4, 37°C Homo sapiens