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Literature summary for 3.4.24.56 extracted from
- Purified recombinant insulin-degrading enzyme degrades amyloid beta-protein but does not promote its oligomerization (2000), Biochem. J., 351, 509-516.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | substrate amyloid beta-protein is an essential factor in the pathogenesis of Alzheimer's disease | Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| polyhistidine- and haemagglutinin-tagged recombinant wild-type and catalytically inactive mutants expressed in bacteria | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| E111Q | catalytically inactive mutant | Homo sapiens |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 110000 | - |
SDS-PAGE | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
human | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| recombinant wild-type and catalytically inactive mutants | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| amyloid beta-protein + H2O | - |
Homo sapiens | ? | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| EC 3.4.22.11 | formerly | Homo sapiens |
| IDE | - |
Homo sapiens |
| Insulin-degrading enzyme | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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