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Literature summary for 3.4.24.56 extracted from

  • Ansorge, S.; Bohley, P.; Kirschke, H.; Langner, J.; Wiederanders, B.
    The insulin and glucagon degrading proteinase of rat liver: a metal-dependent enzyme (1984), Biomed. Biochim. Acta, 43, 39-46.
    View publication on PubMed
Search for more literature for 3.4.24.56

Inhibitors

Inhibitors Comment Organism Structure
1,10-phenanthroline Zn2+, Co2+, Mn2+ and to a smaller extent Cd2+ and Fe2+ are capable of preventing the inhibition Rattus norvegicus
bipyridine
-
 Rattus norvegicus
EDTA
-
 Rattus norvegicus
EGTA
-
 Rattus norvegicus
Indole derivatives
-
 Rattus norvegicus
additional information not: antipain; not: bestatine; not: chymostatin; not: elastatinal; not: leupeptin; not: pepstatin; not: phosphoramidon Rattus norvegicus
SH-group blocking reagents
-
 Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Rattus norvegicus 5829
-

Metals/Ions

Metals/Ions Comment Organism Structure
additional information metalloenzyme, removal of the protein-bound metal(s) results in nearly total and irreversible loss of activity Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Glucagon + H2O
-
 Rattus norvegicus Hydrolyzed glucagon
-
 ?
Insulin + H2O bovine Rattus norvegicus Hydrolyzed insulin
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.1
-
-
 Rattus norvegicus