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Literature summary for 3.4.24.56 extracted from
- Partial purification and characterization of insulin protease and its intracellular inhibitor from rat liver (1984), Arch. Biochem. Biophys., 229, 604-611.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| glutathione | stimulates | Rattus norvegicus |  |
| mercaptoethanol | stimulates | Rattus norvegicus | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Ag+ | - |
Rattus norvegicus | |
| As3+ | - |
Rattus norvegicus | |
| Cu2+ | - |
Rattus norvegicus | |
| EDTA | - |
Rattus norvegicus | |
| EGTA | - |
Rattus norvegicus | |
| Inhibitor from rat liver homogenate | low-molecular-weight protein, order of greatest to least activity: pancreas, liver, kidney, testes, adrenal, lung, spleen, diaphragm, heart, muscle, brain, epididymal fad pad, skin | Rattus norvegicus | |
| NEM | - |
Rattus norvegicus | |
| p-hydroxymercuribenzoate | - |
Rattus norvegicus | |
| Pb4+ | - |
Rattus norvegicus | |
| Sb3+ | - |
Rattus norvegicus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.000024 | - |
Insulin | - |
Rattus norvegicus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | activates (at 1 mM) | Rattus norvegicus | |
| Mg2+ | activates | Rattus norvegicus | |
| Mn2+ | reactivates after EDTA inhibition | Rattus norvegicus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| partial | Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Insulin + H2O | - |
Rattus norvegicus | Hydrolyzed insulin | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.6 | - |
- |
Rattus norvegicus |
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