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Literature summary for 3.4.24.56 extracted from

  • Duckworth, W.C.; Stentz, F.B.; Heinemann, M.; Kitabchi, A.E.
    Initial site of insulin cleavage by insulin protease (1979), Proc. Natl. Acad. Sci. USA, 76, 635-639.
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
insulin + H2O Rattus norvegicus stepwise degradation occurs in vivo, an early step in the process is the cleavage of the B-chain between Tyr16 and Leu17, that renders the molecule susceptible to further degradation by nonspecific proteases ?
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Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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Source Tissue

Source Tissue Comment Organism Textmining
skeletal muscle
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 Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Insulin + H2O specific for insulin Rattus norvegicus Hydrolyzed insulin stepwise degradation occurs in vivo, an early step in the process is the cleavage of the B-chain at Tyr16-Leu17 ?
insulin + H2O stepwise degradation occurs in vivo, an early step in the process is the cleavage of the B-chain between Tyr16 and Leu17, that renders the molecule susceptible to further degradation by nonspecific proteases Rattus norvegicus ?
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 ?