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Literature summary for 3.4.24.56 extracted from
- Insulysin and pitrilysin: insulin-degrading enzymes of mammals and bacteria (1995), Methods Enzymol., 248, 693-703.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| Drosophila melanogaster | Drosophila melanogaster |
| Drosophila melanogaster | Homo sapiens |
| Eimeria bovis | Drosophila melanogaster |
| Eimeria bovis | Homo sapiens |
| human | Drosophila melanogaster |
| human | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| sulfhydryl-modifying reagents | Drosophila, human and rat enzyme inhibited, bacterial enzyme not | Drosophila melanogaster | |
| sulfhydryl-modifying reagents | Drosophila, human and rat enzyme inhibited, bacterial enzyme not | Homo sapiens | |
| sulfhydryl-modifying reagents | Drosophila, human and rat enzyme inhibited, bacterial enzyme not | Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| insulin + H2O | Drosophila melanogaster | implicated in the process of membrane fusion and cell development | ? | - |
? |  |
| insulin + H2O | Mammalia | implicated in the process of membrane fusion and cell development | ? | - |
? | |
| insulin + H2O | Homo sapiens | implicated in the process of membrane fusion and cell development | ? | - |
? | |
| insulin + H2O | Rattus norvegicus | implicated in the process of membrane fusion and cell development | ? | - |
? | |
| insulin + H2O | Drosophila melanogaster | insulin degradation | ? | - |
? | |
| insulin + H2O | Mammalia | insulin degradation | ? | - |
? | |
| insulin + H2O | Homo sapiens | insulin degradation | ? | - |
? | |
| insulin + H2O | Rattus norvegicus | insulin degradation | ? | - |
? | |
| insulin + H2O | Drosophila melanogaster | the enzyme may play a general role in hormone metabolism and cellular regulation | ? | - |
? | |
| insulin + H2O | Mammalia | the enzyme may play a general role in hormone metabolism and cellular regulation | ? | - |
? | |
| insulin + H2O | Homo sapiens | the enzyme may play a general role in hormone metabolism and cellular regulation | ? | - |
? | |
| insulin + H2O | Rattus norvegicus | the enzyme may play a general role in hormone metabolism and cellular regulation | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Drosophila melanogaster | - |
- |
- |
| Homo sapiens | - |
- |
- |
| Mammalia | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
assay methods | Drosophila melanogaster |
| additional information | - |
assay methods | Mammalia |
| additional information | - |
assay methods | Homo sapiens |
| additional information | - |
assay methods | Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Atrial natriuretic factor + H2O | - |
Drosophila melanogaster | ? | - |
? | |
| Atrial natriuretic factor + H2O | - |
Mammalia | ? | - |
? | |
| Atrial natriuretic factor + H2O | - |
Homo sapiens | ? | - |
? | |
| Atrial natriuretic factor + H2O | - |
Rattus norvegicus | ? | - |
? | |
| Glucagon + H2O | - |
Drosophila melanogaster | Hydrolyzed glucagon | - |
? | |
| Glucagon + H2O | - |
Mammalia | Hydrolyzed glucagon | - |
? | |
| Glucagon + H2O | - |
Homo sapiens | Hydrolyzed glucagon | - |
? | |
| Glucagon + H2O | - |
Rattus norvegicus | Hydrolyzed glucagon | - |
? | |
| Insulin + H2O | - |
Drosophila melanogaster | Hydrolyzed insulin | - |
? | |
| Insulin + H2O | - |
Mammalia | Hydrolyzed insulin | - |
? | |
| Insulin + H2O | - |
Homo sapiens | Hydrolyzed insulin | - |
? | |
| Insulin + H2O | - |
Rattus norvegicus | Hydrolyzed insulin | - |
? | |
| insulin + H2O | implicated in the process of membrane fusion and cell development | Drosophila melanogaster | ? | - |
? | |
| insulin + H2O | implicated in the process of membrane fusion and cell development | Mammalia | ? | - |
? | |
| insulin + H2O | implicated in the process of membrane fusion and cell development | Homo sapiens | ? | - |
? | |
| insulin + H2O | implicated in the process of membrane fusion and cell development | Rattus norvegicus | ? | - |
? | |
| insulin + H2O | insulin degradation | Drosophila melanogaster | ? | - |
? | |
| insulin + H2O | insulin degradation | Mammalia | ? | - |
? | |
| insulin + H2O | insulin degradation | Homo sapiens | ? | - |
? | |
| insulin + H2O | insulin degradation | Rattus norvegicus | ? | - |
? | |
| insulin + H2O | the enzyme may play a general role in hormone metabolism and cellular regulation | Drosophila melanogaster | ? | - |
? | |
| insulin + H2O | the enzyme may play a general role in hormone metabolism and cellular regulation | Mammalia | ? | - |
? | |
| insulin + H2O | the enzyme may play a general role in hormone metabolism and cellular regulation | Homo sapiens | ? | - |
? | |
| insulin + H2O | the enzyme may play a general role in hormone metabolism and cellular regulation | Rattus norvegicus | ? | - |
? | |
| Oxidatively damaged hemoglobin + H2O | - |
Drosophila melanogaster | ? | - |
? | |
| Oxidatively damaged hemoglobin + H2O | - |
Mammalia | ? | - |
? | |
| Oxidatively damaged hemoglobin + H2O | - |
Homo sapiens | ? | - |
? | |
| Oxidatively damaged hemoglobin + H2O | - |
Rattus norvegicus | ? | - |
? | |
| Transforming growth factor + H2O | - |
Drosophila melanogaster | ? | - |
? | |
| Transforming growth factor + H2O | - |
Mammalia | ? | - |
? | |
| Transforming growth factor + H2O | - |
Homo sapiens | ? | - |
? | |
| Transforming growth factor + H2O | - |
Rattus norvegicus | ? | - |
? | |
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