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Literature summary for 3.4.24.56 extracted from

  • Ding, L.; Becker, A.B.; Suzuki, A.; Roth, R.A.
    Comparison of the enzymatic and biochemical properties of human insulin-degrading enzyme and Escherichia coli protease III (1992), J. Biol. Chem., 267, 2414-2420.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
1,10-phenanthroline
-
Homo sapiens
bacitracin
-
Homo sapiens
Chelating agents
-
Homo sapiens
EDTA
-
Homo sapiens
additional information not: phenylmethanesulfonyl fluoride; not: phosphoramidon Homo sapiens
NEM
-
Homo sapiens
Sulfhydryl-alkylating agents
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
partial Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Insulin + H2O much better degradation than insulin growth factor II Homo sapiens Hydrolyzed insulin
-
?
Insulin growth factor II + H2O
-
Homo sapiens ?
-
?

Subunits

Subunits Comment Organism
More human enzyme partially exists as homodimer or heterodimer Homo sapiens