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Literature summary for 3.4.24.55 extracted from

  • Ding, L.; Becker, A.B.; Suzuki, A.; Roth, R.A.
    Comparison of the enzymatic and biochemical properties of human insulin-degrading enzyme and Escherichia coli protease III (1992), J. Biol. Chem., 267, 2414-2420.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
bacitracin
-
Escherichia coli
Chelating agents
-
Escherichia coli

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ contains 0.6 mol of zinc per mol of enzyme Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Insulin + H2O degradation in such a way that its receptor binding activity is rapidly lost but its precipitability in trichloroacetic acid is only slightly decreased Escherichia coli Hydrolyzed insulin
-
?
Insulin-like growth factor II + H2O
-
Escherichia coli ?
-
?