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Literature summary for 3.4.24.49 extracted from

  • Oliveira, A.K.; Paes Leme, A.F.; Asega, A.F.; Camargo, A.C.; Fox, J.W.; Serrano, S.M.
    New insights into the structural elements involved in the skin haemorrhage induced by snake venom metalloproteinases (2010), Thromb. Haemost., 104, 485-497.
    View publication on PubMed
Search for more literature for 3.4.24.49

General Stability

General Stability Organism
N-deglycosylation causes loss of structural stability of bothropasin Bothrops jararaca

Organism

Organism UniProt Comment Textmining
Bothrops jararaca
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein N-deglycosylation causes loss of structural stability of bothropasin Bothrops jararaca

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
collagen I + H2O
-
 Bothrops jararaca ?
-
 ?
Collagen IV + H2O
-
 Bothrops jararaca ?
-
 ?
collagen VI + H2O from human placenta Bothrops jararaca ?
-
 ?
Fibrinogen + H2O
-
 Bothrops jararaca ?
-
 ?
fibrinonectin + H2O from human plasma Bothrops jararaca ?
-
 ?
Matrigel + H2O
-
 Bothrops jararaca ?
-
 ?
additional information bothropasin degradation profiles of fibrinogen, fibronectin, vitronectin, von Willebrand factor, collagens IV and VI, laminin and Matrigel in comparison to the other three snake venom metalloproteinases of Bothrops jararaca, binding to plasma and extracellular matrix proteins, overview. Collagen I is degraded only by bothropasin Bothrops jararaca ?
-
 ?
Vitronectin + H2O from human plasma Bothrops jararaca ?
-
 ?
von Willebrand factor + H2O
-
 Bothrops jararaca ?
-
 ?

Subunits

Subunits Comment Organism
More bothropasin is aof P-III class and has a minor carbohydrate moiety and disintegrin-like/cysteine-rich domains Bothrops jararaca

Synonyms

Synonyms Comment Organism
Bothrops jararaca snake venom metalloproteinase
-
 Bothrops jararaca

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Bothrops jararaca

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Bothrops jararaca

General Information

General Information Comment Organism
additional information role of the non-catalytic domains of snake venom metalloproteinases, interaction of four snake venom metalloproteinases of different domain compositions and glycosylation levels, from Bothrops jararaca venom, with plasma and extracellular matrix proteins, overview Bothrops jararaca
physiological function haemorrhagic effect of bothropasin on mouse skin, overview Bothrops jararaca