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Literature summary for 3.4.24.49 extracted from

  • Mandelbaum, F.R.; Assakura, M.T.; Reichl, A.P.; Serrano, S.M.
    Bothropasin (2004), Handbook Of Proteolytic Enzymes(Barrett,A. J. ,Rawlings,N. D. ,Woessner,J. F. ,Eds. )Academic Press, 1, 658-659.
No PubMed abstract available
Search for more literature for 3.4.24.49

Application

Application Comment Organism
medicine local tissue damage after snakebite, causes hemorrhage followed by myonecrosis and arterial necrosis after intramuscular injection of doses of 0.02 mg in mice, myonecrosis is still observed with lower doses down to 0.001 mg Bothrops jararaca

Inhibitors

Inhibitors Comment Organism Structure
1,10-phenanthroline by 2 mM Bothrops jararaca
DTT by 2 mM Bothrops jararaca
EDTA by 2 mM Bothrops jararaca
EGTA by 2 mM Bothrops jararaca

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
37300
-
 denatured and reduced protein in the presence of EDTA, SDS-PAGE, sedimentation equilibrium Bothrops jararaca
48000
-
 SDS-PAGE Bothrops jararaca
49870
-
 sedimentation equilibrium Bothrops jararaca

Organism

Organism UniProt Comment Textmining
Bothrops jararaca
-
-
-

Purification (Commentary)

Purification (Comment) Organism
7fold Bothrops jararaca

Source Tissue

Source Tissue Comment Organism Textmining
venom
-
 Bothrops jararaca
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
casein + H2O enzyme stabilized by CaCl2 Bothrops jararaca ?
-
 ?
Fibrin + H2O
-
 Bothrops jararaca ?
-
 ?
fibrinogen
-
 Bothrops jararaca ?
-
 ?
fibronectin
-
 Bothrops jararaca ?
-
 ?
gelatin
-
 Bothrops jararaca ?
-
 ?
type I collagen
-
 Bothrops jararaca ?
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.8
-
-
 Bothrops jararaca