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Literature summary for 3.4.24.48 extracted from
- Ruberlysin (2004), Handbook Of Proteolytic Enzymes(Barrett,A. J. ,Rawlings,N. D. ,Woessner,J. F. ,Eds. )Academic Press, 1, 682-683.
No PubMed abstract available
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | HT-2 has hemorrhagic and lethal activity | Crotalus ruber ruber |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| EDTA | - |
Crotalus ruber ruber |  |
| additional information | not inhibited by benzamidine | Crotalus ruber ruber |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | 1.1 mol of calcium per mol of protein | Crotalus ruber ruber | |
| Zn2+ | 1.1 mol of zinc per mol of protein | Crotalus ruber ruber | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 25000 | - |
- |
Crotalus ruber ruber |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Crotalus ruber ruber | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| by gel filtration and ion-exchange chromatography | Crotalus ruber ruber |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| venom | - |
Crotalus ruber ruber | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (Met)enkephalin + H2O | cleavage at Gly3-Phe4 | Crotalus ruber ruber | ? | - |
? | |
| angiotensin + H2O | cleavage at Pro7-Phe8 and His6-Pro7 | Crotalus ruber ruber | ? | - |
? | |
| casein + H2O | - |
Crotalus ruber ruber | ? | - |
? | |
| Dimethylcasein + H2O | - |
Crotalus ruber ruber | ? | - |
? | |
| Fibrinogen + H2O | hydrolysis of Aalpha and Bbeta chains, whereas the gamma chain is resistant to hydrolysis | Crotalus ruber ruber | ? | - |
? | |
| hide powder azure + H2O | - |
Crotalus ruber ruber | ? | - |
? | |
| luteinizing hormone releasing hormone + H2O | cleavage at Gly6-Leu7 and Trp3-Ser4 | Crotalus ruber ruber | ? | - |
? | |
| oxidized insulin B chain + H2O | - |
Crotalus ruber ruber | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Hemorrhagic toxin II | - |
Crotalus ruber ruber |
| HT-2 | - |
Crotalus ruber ruber |
| red rattlesnake metalloendopeptidase | - |
Crotalus ruber ruber |
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Release 2023.1 (January 2023)
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