Activating Compound | Comment | Organism | Structure |
---|---|---|---|
heparin | activation, acceleration of antithrombin III inactivation, at a ratio of 6.7:1 (w/w) | Crotalus adamanteus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
EDTA | - |
Crotalus adamanteus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Crotalus adamanteus | - |
Eastern diamondback rattlesnake | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
venom | - |
Crotalus adamanteus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Human antithrombin III + H2O | in the presence of heparin non-inactivating cleavage in aminoterminal region at Glu37-Gln38 followed by inactivating cleavages in carboxyterminal region at Ala375-Ser376 and Ala378-Val379, in the absence of heparin inactivating cleavage in carboxyterminal region at Ser383-Ala384 | Crotalus adamanteus | Hydrolyzed and inactivated antithrombin III | first occuring fragment in the presence of heparin is a still active antithrombin of MW 56000, followed by inactive fragments of MW 50000 and MW 5000, in the absence of heparin only inactive fragments of MW 56000 and MW 5000 occur | ? | |
Human antithrombin III + H2O | MW 60000, at a molar ratio of antithrombin III:enzyme of 40:1, in the presence and absence of heparin | Crotalus adamanteus | Hydrolyzed and inactivated antithrombin III | first occuring fragment in the presence of heparin is a still active antithrombin of MW 56000, followed by inactive fragments of MW 50000 and MW 5000, in the absence of heparin only inactive fragments of MW 56000 and MW 5000 occur | ? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
23 | - |
assay at | Crotalus adamanteus |