Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Collagenase inhibitor SC 44463 | - |
Crotalus atrox | |
cysteine | - |
Crotalus atrox | |
EDTA | - |
Crotalus atrox | |
additional information | iodoacetate; no inhibition by aprotinin, PMSF | Crotalus atrox | |
phosphoramidon | weak, isozyme Ht-d | Crotalus atrox | |
thiorphan | - |
Crotalus atrox |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | zinc metalloproteinase | Crotalus atrox |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
additional information | - |
amino acid composition | Crotalus atrox |
additional information | - |
they differ by a single amino acid substitution at position 181, Ala (Cc) or Asp (Cd) | Crotalus atrox |
23230 | - |
Crotalus atrox, isozyme Ht-d | Crotalus atrox |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Basement membranes surrounding capillaries + H2O | Crotalus atrox | involved in disruption of capillary membranes causing hemorrhage in surrounding tissue | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Crotalus atrox | - |
Western diamondback rattlesnake | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
venom | - |
Crotalus atrox | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-Aminobenzoyl-Ala-Gly-Leu-Ala 4-nitrobenzyl amide + H2O | - |
Crotalus atrox | ? | - |
? | |
Basement membranes surrounding capillaries + H2O | involved in disruption of capillary membranes causing hemorrhage in surrounding tissue | Crotalus atrox | ? | - |
? | |
Collagen type IV + H2O | basement membrane component, alpha1 (MW 185000) and alpha2 (MW 170000) chain | Crotalus atrox | Hydrolyzed collagen type IV | MW 170000, MW 164000, MW 125000, MW 110000, MW 940000 and MW 64000 fragments | ? | |
Gelatin of collagen type I + H2O | i.e. denatured collagen | Crotalus atrox | Hydrolyzed gelatin of collagen type I | MW 60000 and MW 50000 fragments | ? | |
Gelatin of collagen type III + H2O | i.e. denatured collagen | Crotalus atrox | ? | - |
? | |
Gelatin of collagen type V + H2O | i.e. denatured collagen, hydrolysis at 38ΓΈC and above, not below | Crotalus atrox | Hydrolyzed gelatin of collagen type V | MW 130000, MW 118000, MW 93000 and MW 85000 fragments | ? | |
additional information | no hydrolysis of interstitial collagen, native type I collagen | Crotalus atrox | ? | - |
? |