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Literature summary for 3.4.24.42 extracted from
- Studies on the mechanism of hemorrhage production by five proteolytic hemorrhagic toxins from Crotalus atrox venom (1988), Biol. Chem. Hoppe-Seyler, 369, 121-129.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 1,10-phenanthroline | - |
Crotalus atrox |  |
| Amino acid hydroxamates | - |
Crotalus atrox | |
| EDTA | - |
Crotalus atrox | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Zn2+ | zinc metalloproteinase | Crotalus atrox | |
| Zn2+ | 1 mol zinc/mol enzyme | Crotalus atrox | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Crotalus atrox | - |
Western diamondback rattlesnake | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| venom | - |
Crotalus atrox | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Basement membrane preparation + H2O | poor substrate: component band a | Crotalus atrox | Soluble peptides | - |
? | |
| Laminin + H2O | basement membrane component, poor substrate | Crotalus atrox | ? | - |
? | |
| Oxidized insulin B-chain + H2O | cleavage at Gly23-Phe24 | Crotalus atrox | ? | - |
? | |
| Oxidized insulin B-chain + H2O | cleaves the same bonds as atrolysin B and A (the latter except Gly23-Phe24) | Crotalus atrox | ? | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Crotalus atrox |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| additional information | - |
pI: 6 (isozyme Cc), pI: 6.1 (isozyme Cd) | Crotalus atrox |
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