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Literature summary for 3.4.24.36 extracted from

  • Gomez, M.A.; Contreras, I.; Halle, M.; Tremblay, M.L.; McMaster, R.W.; Olivier, M.
    Leishmania GP63 alters host signaling through cleavage-activated protein tyrosine phosphatases (2009), Sci. Signal., 2, ra58.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
additional information GP63 is located in punctuated structures along the cell periphery in infected macrophages, with partial colocalization with the lipid raft marker cholera toxin B Leishmania sp.
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
protein tyrosine phosphatase PTP1B + H2O Leishmania sp. activation and posttranslationally modification of host enzymes in infected macrophages. The PTP1B cleavage fragments are enzymatically active. The mechanism underlying PTP modulation involves the proteolytic activity of the Leishmania surface protease GP63 ?
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protein tyrosine phosphatase SHP-1 + H2O Leishmania sp. activation and posttranslationally modification of host enzymes in infected macrophages. The SHP-1 cleavage fragments are enzymatically active ?
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?
protein tyrosine phosphatase TCPTP + H2O Leishmania sp. activation and posttranslationally modification of host enzymes in infected macrophages. The TCPTP cleavage fragments are enzymatically active ?
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?

Organism

Organism UniProt Comment Textmining
Leishmania sp.
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propagated in B10R murine MO cell line
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
protein tyrosine phosphatase PTP1B + H2O activation and posttranslationally modification of host enzymes in infected macrophages. The PTP1B cleavage fragments are enzymatically active. The mechanism underlying PTP modulation involves the proteolytic activity of the Leishmania surface protease GP63 Leishmania sp. ?
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?
protein tyrosine phosphatase PTP1B + H2O activation and posttranslationally modification of host enzymes in infected macrophages Leishmania sp. ?
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?
protein tyrosine phosphatase SHP-1 + H2O activation and posttranslationally modification of host enzymes in infected macrophages. The SHP-1 cleavage fragments are enzymatically active Leishmania sp. ?
-
?
protein tyrosine phosphatase SHP-1 + H2O activation and posttranslationally modification of host enzymes in infected macrophages Leishmania sp. ?
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?
protein tyrosine phosphatase TCPTP + H2O activation and posttranslationally modification of host enzymes in infected macrophages. The TCPTP cleavage fragments are enzymatically active Leishmania sp. ?
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?
protein tyrosine phosphatase TCPTP + H2O activation and posttranslationally modification of host enzymes in infected macrophages Leishmania sp. ?
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?

Synonyms

Synonyms Comment Organism
gp63
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Leishmania sp.
surface protease GP63
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Leishmania sp.

General Information

General Information Comment Organism
physiological function GP63 is a key Leishmania virulence factor. Leishmania GP63 alters the profile of protein tyrosine phosphatases associated with JAK-2 at the host cell plasma membrane Leishmania sp.