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Literature summary for 3.4.24.36 extracted from
- Leishmanolysin-like molecules in Herpetomonas samuelpessoai mediate hydrolysis of protein substrates and interaction with insect (2010), Protist, 161, 589-602.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cell surface | surface molecules are glycosylphosphatidylinositol-anchored | Herpetomonas pessoai | 9986 | - |
| cytoplasm | - |
Herpetomonas pessoai | 5737 | - |
| extracellular | the enzyme is secreted. The zinc-metallopeptidase inhibitor 1,10-phenanthroline is able to restrain the secretion of the metallopeptidase in a dose-dependent manner, while the phospholipase C inhibitor 4-chloromercuriphenylsulfonic acid does not alter the secretion pattern | Herpetomonas pessoai | - |
- |
| membrane | - |
Herpetomonas pessoai | 16020 | - |
| additional information | leishmanolysin-like molecules are distributed in different cellular compartments, immunocytochemic analysis, overview. The expression of leishmanolysin-like molecules is not modulated during either temperature- or dimethylsulfoxide-elicited differentiation | Herpetomonas pessoai | - |
- |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| additional information | zinc-metallopeptidase | Herpetomonas pessoai |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 66000 | - |
x * 66000, SDS-PAGE | Herpetomonas pessoai |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Herpetomonas pessoai | the enzyme shows a broad substrate spectrum and ability to degrade albumin,hemoglobin, IgG, mucin, casein, and gut proteins obtained from Aedes aegypti | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Herpetomonas pessoai | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| promastigote | - |
Herpetomonas pessoai | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | the enzyme shows a broad substrate spectrum and ability to degrade albumin,hemoglobin, IgG, mucin, casein, and gut proteins obtained from Aedes aegypti | Herpetomonas pessoai | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 66000, SDS-PAGE | Herpetomonas pessoai |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 66 kDa surface metallopeptidase | - |
Herpetomonas pessoai |
| leishmanolysin-like molecule | - |
Herpetomonas pessoai |
| surface leishmanolysin-like molecule | - |
Herpetomonas pessoai |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
- |
Herpetomonas pessoai |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6 | - |
- |
Herpetomonas pessoai |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| additional information | - |
the surface metallopeptidase is active at a broad spectrum of pH | Herpetomonas pessoai |
General Information
| General Information | Comment | Organism |
|---|---|---|
| additional information | Herpetomonas samuelpessoai cells are able to colonize the gut of Aedes aegypti, but the pretreatment of gut cells with purified leishmanolysin-like protein drastically diminishes the adhesion, overview. The expression of surface leishmanolysin in Herpetomonas samuelpessoai cells is drastically enhanced after passage in Aedes aegypti | Herpetomonas pessoai |
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Release 2023.1 (January 2023)
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