Protein Variants | Comment | Organism |
---|---|---|
additional information | leishmanolysin-knock out mutants show a substantially higher sensitivity to inhibitors and their antileishmanial activity, such as members of the alpha- and phi-defensins, magainins and cathelicidins, pexiganan-treatment of knock out mutants induces disruption of surface-membrane permeability and expression of features of apoptosis including smaller cell size, loss of mitochondrial membrane potential, exposure of surface phosphatidyl serine as well as induction of caspase 3/7 activity, phenotype and pexiganan cleavage products generated by leishmanolysin degradation, overview | Leishmania major |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cell surface | - |
Leishmania major | 9986 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Leishmania major | the major surface-metalloprotease is a virulence factor which contributes to a variety of functions including evasion of complement-mediated parasite-killing and host intramacrophage survival, the protozoan enzyme protects the parasite against antimicrobial peptide-induced apoptotic killing by the host cell, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Leishmania major | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the major surface-metalloprotease is a virulence factor which contributes to a variety of functions including evasion of complement-mediated parasite-killing and host intramacrophage survival, the protozoan enzyme protects the parasite against antimicrobial peptide-induced apoptotic killing by the host cell, overview | Leishmania major | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
major surface-metalloprotease | - |
Leishmania major |