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Literature summary for 3.4.24.36 extracted from

  • Hsiao, C.C.; Yao, C.; Storlie, P.; Donelson, J.E.; Wilson, M.E.
    The major surface protease (MSP or GP63) in the intracellular amastigote stage of Leishmania chagasi (2008), Mol. Biochem. Parasitol., 157, 148-159.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.36

Inhibitors

Inhibitors Comment Organism Structure
1,10-phenanthroline
-
 Leishmania chagasi

Localization

Localization Comment Organism GeneOntology No. Textmining
cell surface two-third of MSPs in promastigotes is orientated along the cell surface, whereas most MSPs in amastigotes are localized in the flagellar pocket Leishmania chagasi 9986
-
cytosol most MSPs in promastigotes are membrane-associated, whereas most MSPs in amastigotes are cytosolic Leishmania chagasi 5829
-
extracellular promastigote MSP is shed extracellularly, whereas MSPs from axenic amastigotes are not shed Leishmania chagasi
-
-
flagellar pocket two-third of MSPs in promastigotes is orientated along the cell surface, whereas most MSPs in amastigotes are localized in the flagellar pocket Leishmania chagasi
-
-
plasma membrane most MSPs in promastigotes are membrane-associated, whereas most MSPs in amastigotes are cytosolic Leishmania chagasi 5886
-

Metals/Ions

Metals/Ions Comment Organism Structure
additional information MSPs are metalloproteinases Leishmania chagasi

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
51674
-
 x * 59177, MSPC, sequence calculation, x * 51689, MSPS, sequence calculation, x * 51674, MSPL, sequence calculation Leishmania chagasi
51689
-
 x * 59177, MSPC, sequence calculation, x * 51689, MSPS, sequence calculation, x * 51674, MSPL, sequence calculation Leishmania chagasi
59177
-
 x * 59177, MSPC, sequence calculation, x * 51689, MSPS, sequence calculation, x * 51674, MSPL, sequence calculation Leishmania chagasi

Organism

Organism UniProt Comment Textmining
Leishmania chagasi
-
 three genes encoding the enzyme: MSPS, MSPL, and MSPC
-
Leishmania chagasi MHOM/BR/00/1669
-
 three genes encoding the enzyme: MSPS, MSPL, and MSPC
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein most MSPs in promastigotes are N-glycosylated, while in amastigotes they are not Leishmania chagasi

Source Tissue

Source Tissue Comment Organism Textmining
amastigote expresses the genes MSPL and MSPC Leishmania chagasi
-
additional information MSP multiple forms expression analysis during parasite life stages, overview Leishmania chagasi
-
promastigote expresses the genes MSPS, MSPL, and two forms of MSPC Leishmania chagasi
-

Subunits

Subunits Comment Organism
? x * 59177, MSPC, sequence calculation, x * 51689, MSPS, sequence calculation, x * 51674, MSPL, sequence calculation Leishmania chagasi

Synonyms

Synonyms Comment Organism
gp63
-
 Leishmania chagasi
major surface protease
-
 Leishmania chagasi
MSP
-
 Leishmania chagasi

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5.5
-
 amastigote MSPS Leishmania chagasi
6 8 promastigote MSPS Leishmania chagasi

pI Value

Organism Comment pI Value Maximum pI Value
Leishmania chagasi MSPC
-
 5.32
Leishmania chagasi MSPS and MSPL
-
 5.65