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Literature summary for 3.4.24.36 extracted from
- Internal and surface-localized major surface proteases of Leishmania spp. and their differential release from promastigotes (2007), Eukaryot. Cell, 6, 1905-1912.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cell surface | - |
Leishmania chagasi | 9986 | - |
| extracellular | - |
Leishmania chagasi | - |
- |
| intracellular | - |
Leishmania chagasi | 5622 | - |
| additional information | three pools of MSP, located either internally within the parasite, anchored to the surface membrane, or released into the extracellular environment, promastigotes incubation with Matrigel matrix, a soluble basement membrane extract of Engelbreth-Holm-Swarm tumor cells, stimulates the release of internal MSP but not of surface-located MSP, at 37°C, overview | Leishmania chagasi | - |
- |
| plasma membrane | - |
Leishmania chagasi | 5886 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Leishmania chagasi | major surface protease is a virulence factor of Leishmania spp. protozoan, virulent Leishmania chagasi undergoes a growth-associated lengthening in the t1/2 of surface-localized MSP, but this does not occur in the attenuated L5 strain, surface-localized MSP isoforms are differently regulated in attenuated and virulent strains, overview | ? | - |
? |  |
| additional information | Leishmania chagasi MHOM/BR/00/1669 | major surface protease is a virulence factor of Leishmania spp. protozoan, virulent Leishmania chagasi undergoes a growth-associated lengthening in the t1/2 of surface-localized MSP, but this does not occur in the attenuated L5 strain, surface-localized MSP isoforms are differently regulated in attenuated and virulent strains, overview | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Leishmania chagasi | - |
- |
- |
| Leishmania chagasi MHOM/BR/00/1669 | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| amastigote | isolated from the spleens of infected hamsters and transformed to promastigotes at 26°C | Leishmania chagasi | - |
| promastigote | - |
Leishmania chagasi | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | major surface protease is a virulence factor of Leishmania spp. protozoan, virulent Leishmania chagasi undergoes a growth-associated lengthening in the t1/2 of surface-localized MSP, but this does not occur in the attenuated L5 strain, surface-localized MSP isoforms are differently regulated in attenuated and virulent strains, overview | Leishmania chagasi | ? | - |
? | |
| additional information | major surface protease is a virulence factor of Leishmania spp. protozoan, virulent Leishmania chagasi undergoes a growth-associated lengthening in the t1/2 of surface-localized MSP, but this does not occur in the attenuated L5 strain, surface-localized MSP isoforms are differently regulated in attenuated and virulent strains, overview | Leishmania chagasi MHOM/BR/00/1669 | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| gp63 | - |
Leishmania chagasi |
| major surface protease | - |
Leishmania chagasi |
| MSP | - |
Leishmania chagasi |
pI Value
| Organism | Comment | pI Value Maximum | pI Value |
|---|---|---|---|
| Leishmania chagasi | 8 different bands of isozymes within this range | 6.7 | 5.8 |
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Release 2023.1 (January 2023)
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