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Literature summary for 3.4.24.36 extracted from

  • Sadlova, J.; Volf, P.; Victoir, K.; Dujardin, J.C.; Votypka, J.
    Virulent and attenuated lines of Leishmania major: DNA karyotypes and differences in metalloproteinase GP63 (2006), Folia Parasitol., 53, 81-90.
    View publication on PubMed
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Application

Application Comment Organism
medicine parasite virulence is not simply correlated with the activity of enzyme. Enzyme plays a significant role in association with other surface molecules, especially lipophosphoglycan. Overexpression of enzyme can compensate lipophosphoglycan defect in the vertebrate host but in sand flies both molecules fulfill quite different functions Leishmania major

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Leishmania major enzyme plays a significant role in association with other surface molecules, especially lipophosphoglycan. Overexpression of enzyme can compensate lipophosphoglycan defect in the vertebrate host but in sand flies both molecules fulfill quite different functions ?
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Organism

Organism UniProt Comment Textmining
Leishmania major
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 comparison of enzyme in different strains. Considerable variability in amount and proteolytical activity of enzyme among the strains. Attenuated LV561/AV line shows low amount and low enzymatic activity. Strains L119, Neal defective in lipophosphoglycan exhibit enzyme overexpression
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Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information enzyme plays a significant role in association with other surface molecules, especially lipophosphoglycan. Overexpression of enzyme can compensate lipophosphoglycan defect in the vertebrate host but in sand flies both molecules fulfill quite different functions Leishmania major ?
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 ?