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Literature summary for 3.4.24.35 extracted from

  • Zhu, G.; Kang, L.; Wei, Q.; Cui, X.; Wang, S.; Chen, Y.; Jiang, Y.
    Expression and regulation of MMP1, MMP3, and MMP9 in the chicken ovary in response to gonadotropins, sex hormones, and TGFB1 (2014), Biol. Reprod., 90, 57.
    View publication on PubMed
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Cloned(Commentary)

Cloned (Comment) Organism
gene MMP9, quantitative expression analysis Gallus gallus

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular the enzyme is secreted by granulosa cells Gallus gallus
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Organism

Organism UniProt Comment Textmining
Gallus gallus F1NGT3
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Gallus gallus White leghorn F1NGT3
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Source Tissue

Source Tissue Comment Organism Textmining
granulosa cell
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 Gallus gallus
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additional information immunohistochemic localization analysis, overview Gallus gallus
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ovary gene MMP9 is significantly upregulated in 23-wk-old (laying phase) chicken ovaries compared with 6-wk-old ovaries (prepubertal phase). In reproductively active chicken ovary, the enzyme expression level increases during follicular maturation. Enzyme MMP9 mRNA expression continues to rise in postovulatory follicle 1 and postovulatory follicle 2 after ovulation Gallus gallus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Gelatin + H2O
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 Gallus gallus ?
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 ?
Gelatin + H2O
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 Gallus gallus White leghorn ?
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 ?

Synonyms

Synonyms Comment Organism
MMP9
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 Gallus gallus

Expression

Organism Comment Expression
Gallus gallus the mRNA of MMP9 in the granulosa cells is induced by TGFB1 but not follicle-stimulating hormone, luteinizing hormone, progesterone, or estrogen. Luciferase reporter and mutagenesis analysis indicate the AP1 and NFkappaB elements located in the promoter region from -1700 to -2400 bp are critical for both basal and TGFB1-induced MMP9 transcription up

General Information

General Information Comment Organism
additional information enzymes MMP1, MMP3, and MMP9 are synthesized and secreted by granulosa cells of different follicles in the chicken ovary, overview. The three MMP genes (MMP1, MMP3, and MMP9) are significantly upregulated in 23-wk-old (laying phase) chicken ovaries compared with 6-wk-old ovaries (prepubertal phase). In reproductively active chicken ovary, MMP1 expression (both mRNA and protein) remains low in prehierarchical and preovulatory follicles but increases in postovulatory follicles (POFs). Both MMP3 and MMP9 expression levels increase during follicular maturation. MMP3 reaches maximal expression in the first largest follicle (F1), while MMP9 levels continue to rise in POF1 and POF2 after ovulation Gallus gallus