Inhibitors | Comment | Organism | Structure |
---|---|---|---|
BB1101 | MMP inhibitor | Rattus norvegicus | |
GM6001 | MMP inhibitor, complete inhibition at 0.025 mM | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Rattus norvegicus | - |
microvessel | - |
Rattus norvegicus | - |
telencephalon | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Gelatin + H2O | - |
Rattus norvegicus | ? | - |
? | |
occludin + H2O | - |
Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
matrix metalloproteinase-9 | - |
Rattus norvegicus |
MMP-9 | - |
Rattus norvegicus |
Organism | Comment | Expression |
---|---|---|
Rattus norvegicus | normobaric hyperoxia inhibits MMP-9-mediated occludin degradation in the ischemic hemispheric microvessels | down |
Rattus norvegicus | ischemia and reperfusion induce an upregulation of MMP-9 in the ischemic hemispheric microvessels | up |
General Information | Comment | Organism |
---|---|---|
physiological function | MMP-9- mediated occludin degradation represents an important mechanism for blood brain barrier disruption in ischemic stroke | Rattus norvegicus |