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Literature summary for 3.4.24.35 extracted from

  • Kolaczkowska, E.; Koziol, A.; Plytycz, B.; Arnold, B.; Opdenakker, G.
    Altered apoptosis of inflammatory neutrophils in MMP-9-deficient mice is due to lower expression and activity of caspase-3 (2009), Immunol. Lett., 126, 73-82.
    View publication on PubMed

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ MMP-9 is a Zn2+-dependent endopeptidase Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
neutrophil
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Gelatin + H2O
-
Mus musculus ?
-
?

Synonyms

Synonyms Comment Organism
gelatinase B
-
Mus musculus
matrix metalloproteinase-9
-
Mus musculus
MMP-9
-
Mus musculus

General Information

General Information Comment Organism
malfunction in mice lacking MMP-9 the enhanced COX-1-PGE2 decreases caspase-3 expression and activity leading to impaired apoptosis of inflammatory neutrophils resulting in abnormal accumulation of the cells at the inflammatory focus Mus musculus
physiological function MMP-9 is a key enzyme in neutrophil biology Mus musculus