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Literature summary for 3.4.24.35 extracted from

  • Li, H.; Mittal, A.; Makonchuk, D.Y.; Bhatnagar, S.; Kumar, A.
    Matrix metalloproteinase-9 inhibition ameliorates pathogenesis and improves skeletal muscle regeneration in muscular dystrophy (2009), Hum. Mol. Genet., 18, 2584-2598.
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine pharmacological inhibition of MMP-9 activity ameliorates skeletal muscle pathogenesis and enhanced myofiber regeneration in mdx mice. MMP-9 represents as one of the most promising therapeutic targets for the prevention of disease progression in Duchenne muscular dystrophy Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
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-
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Source Tissue

Source Tissue Comment Organism Textmining
macrophage macrophages contribute significantly to the elevated levels of MMP-9 in dystrophic muscle Mus musculus
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skeletal muscle
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 Mus musculus
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Synonyms

Synonyms Comment Organism
matrix metalloproteinase-9
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 Mus musculus
MMP-9
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 Mus musculus

Expression

Organism Comment Expression
Mus musculus in vivo administration of a nuclear factor-kappa B inhibitory peptide blocks the expression of MMP-9 in dystrophic muscle of mdx mice down
Mus musculus the mRNA levels of MMP-9 are significantly higher in diaphragm muscle from 3-, 6- and 8-week-old mdx mice compared with age-matched C57BL/10 control mice up

General Information

General Information Comment Organism
malfunction increased levels of MMP-9 protein cause myopathy in dystrophin-deficient mdx mice. Deletion of Mmp9 gene in mdx mice improves skeletal muscle structure and functions and reduces muscle injury, inflammation and fiber necrosis. Heterozygous or homozygous deletion of MMP-9 attenuates accumulation of macrophages, fiber necrosis and improves force production in skeletal muscle of mdx mice. Genetic deletion of MMP-9 attenuates fibrosis in diaphragm of mdx mice. Genetic ablation of MMP-9 inhibits the activation of activator protein-1 and nuclear factor-kappaB transcription factors, reduces the serum level of creatine kinase and improves skeletal muscle structure in mdx mice. Genetic ablation of MMP-9 augments myofiber regeneration, improves sarcolemmal structure and augments the cellular levels of beta-dystroglycan and nNOS in skeletal muscle of mdx mice Mus musculus