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Literature summary for 3.4.24.35 extracted from

  • Dong, X.; Song, Y.N.; Liu, W.G.; Guo, X.L.
    MMP-9, a potential target for cerebral ischemic treatment (2009), Curr. Neuropharmacol., 7, 269-275.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.35

Application

Application Comment Organism
medicine MMP-9 is a potential target for cerebral ischemic treatment in human stroke therapy Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
88000
-
 activated enzyme Homo sapiens
92000
-
 inactive enzyme form Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Aggrecan core protein + H2O Homo sapiens
-
 ?
-
 ?
collagen type IV + H2O Homo sapiens
-
 ?
-
 ?
collagen type V + H2O Homo sapiens
-
 ?
-
 ?
collagen type XI + H2O Homo sapiens
-
 ?
-
 ?
Gelatin + H2O Homo sapiens
-
 ?
-
 ?
Laminin + H2O Homo sapiens
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Homo sapiens
-
cEND cell
-
 Homo sapiens
-
endothelial cell
-
 Homo sapiens
-
serum
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Aggrecan core protein + H2O
-
 Homo sapiens ?
-
 ?
collagen type IV + H2O
-
 Homo sapiens ?
-
 ?
collagen type V + H2O
-
 Homo sapiens ?
-
 ?
collagen type XI + H2O
-
 Homo sapiens ?
-
 ?
Gelatin + H2O
-
 Homo sapiens ?
-
 ?
Laminin + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
gelatinase B
-
 Homo sapiens
matrix metalloproteinase-9
-
 Homo sapiens
MMP-9
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens the antihemorrhagic effect of PJ34, a potent PARP inhibitor, is associated with a 57% decrease in MMP-9 overexpression, glucocorticoid increases TIMP-1 in the brain endothelial cell line cEND to reduce the levels of MMP-9 down
Homo sapiens the expression of MMP-9 is elevated after cerebral ischemia, expression of MMP-9 increases after permanent middle cerebral artery occlusion and transient middle cerebral artery occlusion. interleukin-1beta, tissue necrosis factor-alpha, fibroblast growth facor, and epidermal growth factor can stimulate the secretion of MMP-9 up

General Information

General Information Comment Organism
physiological function MMP-9 plays an important role in wound healing, angiogenesis, inflammation, tumor invasion, and metastasis Homo sapiens