Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P22894 | - |
- |
Mus musculus | O70138 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HUVEC cell | - |
Homo sapiens | - |
General Information | Comment | Organism |
---|---|---|
physiological function | aortic rings isolated from MMP8 -/- apoE -/- mice have less endothelial cell sprouting, and endothelial cells in MMP8 -/- apoE -/- mice have a lower ability to migrate into Matrigel plugs and less capacity of proliferation and angiogenesis. MMP8 -/- apoE -/- and MMP8 +/+- apoE -/- mice fed a Western diet for 12 have small lesion size and less endothelial cells within atherosclerotic lesions | Mus musculus |
physiological function | knockdown of MMP-8 in human umbilical vein endothelial cells with MMP-8 shRNA lentivirus results in a decrease in in vitro capillary-like network formation, cell proliferation and migration, and impairs its capacity of in vivo angiogenesis. Less nuclear accumulation of beta-catenin and lower beta-catenin target gene expression levels are observed in the HuVECs expressing lower levels of endogenous MMP-8. MMP8 is expressed in microvessels within human atherosclerotic plaques and aneurysm. Knockdown of endogenous MMP-8 down-regulates platelet/endothelial cell adhesion molecule PECAM-1 expression by converting less angiotensin I to II, which is an inducer for PECAM-1 gene expression | Homo sapiens |