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Literature summary for 3.4.24.34 extracted from

  • Fang, C.; Wen, G.; Zhang, L.; Lin, L.; Moore, A.; Wu, S.; Ye, S.; Xiao, Q.
    An important role of matrix metalloproteinase-8 in angiogenesis in vitro and in vivo (2013), Cardiovasc. Res., 99, 146-155.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Homo sapiens P22894
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Mus musculus O70138
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Source Tissue

Source Tissue Comment Organism Textmining
HUVEC cell
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Homo sapiens
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General Information

General Information Comment Organism
physiological function aortic rings isolated from MMP8 -/- apoE -/- mice have less endothelial cell sprouting, and endothelial cells in MMP8 -/- apoE -/- mice have a lower ability to migrate into Matrigel plugs and less capacity of proliferation and angiogenesis. MMP8 -/- apoE -/- and MMP8 +/+- apoE -/- mice fed a Western diet for 12 have small lesion size and less endothelial cells within atherosclerotic lesions Mus musculus
physiological function knockdown of MMP-8 in human umbilical vein endothelial cells with MMP-8 shRNA lentivirus results in a decrease in in vitro capillary-like network formation, cell proliferation and migration, and impairs its capacity of in vivo angiogenesis. Less nuclear accumulation of beta-catenin and lower beta-catenin target gene expression levels are observed in the HuVECs expressing lower levels of endogenous MMP-8. MMP8 is expressed in microvessels within human atherosclerotic plaques and aneurysm. Knockdown of endogenous MMP-8 down-regulates platelet/endothelial cell adhesion molecule PECAM-1 expression by converting less angiotensin I to II, which is an inducer for PECAM-1 gene expression Homo sapiens