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Literature summary for 3.4.24.34 extracted from

  • Quintero, P.A.; Knolle, M.D.; Cala, L.F.; Zhuang, Y.; Owen, C.A.
    Matrix metalloproteinase-8 inactivates macrophage inflammatory protein-1 alpha to reduce acute lung inflammation and injury in mice (2010), J. Immunol., 184, 1575-1588.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.34

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane membrane-bound MMP-8 is a more potent MIP-1alpha-degrading enzyme than soluble MMP-8 Mus musculus 16020
-
soluble membrane-bound MMP-8 is a more potent MIP-1alpha-degrading enzyme than soluble MMP-8 Mus musculus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
macrophage inflammatory protein-1 (MIP-1) alpha + H2O Mus musculus membrane-bound MMP-8 is a more potent MIP-1alpha-degrading enzyme than soluble MMP-8 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
macrophage inflammatory protein-1 (MIP-1) alpha + H2O membrane-bound MMP-8 is a more potent MIP-1alpha-degrading enzyme than soluble MMP-8 Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
MMP-8
-
 Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Mus musculus

General Information

General Information Comment Organism
malfunction MMP-8-/- mice with acute lung injury have greater increases in lung polymorphonuclear neutrophils (PMNs) and macrophage counts, measures of alveolar capillary barrier injury, lung elastance, and mortality than wild-type mice with acute lung injury Mus musculus
physiological function MMP-8 inactivates macrophage inflammatory protein-1alpha to reduce acute lung inflammation and injury in mice Mus musculus